FBXO31 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0016567Biological processprotein ubiquitination
GO_0031145Biological processanaphase-promoting complex-dependent catabolic process
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0031571Biological processmitotic G1 DNA damage checkpoint signaling
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0043025Cellular componentneuronal cell body
GO_0005515Molecular functionprotein binding
GO_0030332Molecular functioncyclin binding

IV. Literature review

[source]
Gene nameFBXO31
Protein nameF-box only protein 31
F-box protein 31
SynonymsFBX31
hCG_1980666
PP2386
FBX14
DescriptionFUNCTION: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. .

AccessionsENST00000311635.12 [Q5XUX0-1]
A0A1B0GV77
ENST00000618298.6
ENST00000636077.2
Q5XUX0
A0A0C4DGU8
H3BQG7
ENST00000565593.1