CUL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0140627Biological processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_0030891Cellular componentVCB complex
GO_0044877Molecular functionprotein-containing complex binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0160072Molecular functionubiquitin ligase complex scaffold activity

IV. Literature review

[source]
Gene nameCUL2
Protein nameCullin-2 (CUL-2)
Cullin 2
Synonyms
DescriptionFUNCTION: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins . CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme . The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 . The functional specificity of the ECS complex depends on the substrate recognition component . ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) . A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins . ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). .

AccessionsENST00000691974.1 [Q13617-1]
ENST00000684965.1
A0A8I5KTY2
A0A8I5KVE2
ENST00000691962.1
Q5T2B7
ENST00000687194.1
A0A8I5KQQ5
ENST00000689705.1
ENST00000686748.1
ENST00000374754.9
ENST00000686302.1
ENST00000689330.1
A0A8I5KYM7
Q5T2B5
ENST00000690789.1
ENST00000421317.5 [Q13617-2]
A0A8I5KPX0
A0A8I5KXB2
ENST00000478044.2
ENST00000374749.8 [Q13617-1]
ENST00000691201.1
A0A8I5KV54
A0A8I5KYP8
ENST00000684955.1
A0A0D9SET6
ENST00000691635.1
A0A8I5KYA3
Q13617
A0A8I5KTY5
A0A8I5KP04
A0A8I5KSW7
ENST00000685421.1
ENST00000691457.1
ENST00000374746.6
A0A8I5KR51
ENST00000693739.1
A0A8I5KUA0
A0A8I5KYZ8
ENST00000685681.1
ENST00000690092.1
ENST00000685488.1
ENST00000686156.1
ENST00000690393.1 [Q13617-1]
A0A8I5KU22
ENST00000688571.1
ENST00000688736.1
ENST00000691263.1
A0A8I5KVR3
ENST00000687524.1
ENST00000374748.5 [Q13617-1]
A0A8I5KS98
A0A8I5KY75
ENST00000468804.6
A0A8I5QKN3
A0A8I5QJI3
A0A8I5KWB8
ENST00000691272.1
ENST00000691858.1
ENST00000374751.7 [Q13617-1]
ENST00000688541.1
ENST00000690123.1
ENST00000673636.2 [Q13617-1]
ENST00000686903.1
ENST00000537177.6
A0A8I5KUA9
ENST00000626172.3
A0A0A0MTN0