Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 9 studies | 22% ± 7% | |
macrophage | 6 studies | 20% ± 4% | |
microglial cell | 5 studies | 21% ± 5% | |
epithelial cell | 5 studies | 29% ± 8% | |
GABAergic neuron | 4 studies | 40% ± 14% | |
astrocyte | 4 studies | 28% ± 7% | |
glutamatergic neuron | 4 studies | 50% ± 18% | |
oligodendrocyte | 4 studies | 25% ± 2% | |
myeloid cell | 3 studies | 18% ± 3% | |
lymphocyte | 3 studies | 18% ± 3% | |
oligodendrocyte precursor cell | 3 studies | 28% ± 6% | |
dendritic cell | 3 studies | 22% ± 7% | |
basal cell | 3 studies | 24% ± 7% | |
interneuron | 3 studies | 39% ± 19% | |
neuron | 3 studies | 28% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1886.00 | 1445 / 1445 | 100% | 29.24 | 183 / 183 |
stomach | 100% | 1562.04 | 359 / 359 | 100% | 24.68 | 286 / 286 |
uterus | 100% | 1910.98 | 170 / 170 | 100% | 29.52 | 459 / 459 |
breast | 100% | 1889.70 | 459 / 459 | 100% | 34.38 | 1117 / 1118 |
lung | 100% | 1702.57 | 577 / 578 | 100% | 26.47 | 1155 / 1155 |
bladder | 100% | 2004.90 | 21 / 21 | 100% | 26.75 | 503 / 504 |
prostate | 100% | 1543.99 | 245 / 245 | 100% | 21.23 | 501 / 502 |
ovary | 100% | 1550.10 | 180 / 180 | 100% | 24.35 | 429 / 430 |
brain | 100% | 1844.44 | 2632 / 2642 | 100% | 24.10 | 705 / 705 |
intestine | 100% | 2119.20 | 966 / 966 | 100% | 23.95 | 525 / 527 |
liver | 100% | 1064.33 | 226 / 226 | 100% | 16.50 | 404 / 406 |
thymus | 100% | 1653.49 | 653 / 653 | 100% | 20.67 | 602 / 605 |
kidney | 100% | 1336.91 | 89 / 89 | 99% | 18.46 | 891 / 901 |
pancreas | 99% | 1004.80 | 326 / 328 | 99% | 20.94 | 177 / 178 |
adrenal gland | 100% | 2058.02 | 258 / 258 | 98% | 21.48 | 226 / 230 |
skin | 100% | 2362.95 | 1809 / 1809 | 93% | 22.89 | 441 / 472 |
adipose | 100% | 2011.38 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 25.41 | 29 / 29 |
muscle | 100% | 3221.67 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1825.53 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 28.28 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.10 | 1 / 1 |
blood vessel | 100% | 1810.49 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 97% | 1401.63 | 833 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 76% | 1218.58 | 710 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 73% | 10.05 | 58 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0097193 | Biological process | intrinsic apoptotic signaling pathway |
GO_0031146 | Biological process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
GO_0140627 | Biological process | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
GO_0000082 | Biological process | G1/S transition of mitotic cell cycle |
GO_0019005 | Cellular component | SCF ubiquitin ligase complex |
GO_0005730 | Cellular component | nucleolus |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0031462 | Cellular component | Cul2-RING ubiquitin ligase complex |
GO_0030891 | Cellular component | VCB complex |
GO_0044877 | Molecular function | protein-containing complex binding |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0005515 | Molecular function | protein binding |
GO_0160072 | Molecular function | ubiquitin ligase complex scaffold activity |
Gene name | CUL2 |
Protein name | Cullin-2 (CUL-2) Cullin 2 |
Synonyms | |
Description | FUNCTION: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins . CUL2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme . The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 . The functional specificity of the ECS complex depends on the substrate recognition component . ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) . A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins . ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). . |
Accessions | ENST00000691974.1 [Q13617-1] ENST00000684965.1 A0A8I5KTY2 A0A8I5KVE2 ENST00000691962.1 Q5T2B7 ENST00000687194.1 A0A8I5KQQ5 ENST00000689705.1 ENST00000686748.1 ENST00000374754.9 ENST00000686302.1 ENST00000689330.1 A0A8I5KYM7 Q5T2B5 ENST00000690789.1 ENST00000421317.5 [Q13617-2] A0A8I5KPX0 A0A8I5KXB2 ENST00000478044.2 ENST00000374749.8 [Q13617-1] ENST00000691201.1 A0A8I5KV54 A0A8I5KYP8 ENST00000684955.1 A0A0D9SET6 ENST00000691635.1 A0A8I5KYA3 Q13617 A0A8I5KTY5 A0A8I5KP04 A0A8I5KSW7 ENST00000685421.1 ENST00000691457.1 ENST00000374746.6 A0A8I5KR51 ENST00000693739.1 A0A8I5KUA0 A0A8I5KYZ8 ENST00000685681.1 ENST00000690092.1 ENST00000685488.1 ENST00000686156.1 ENST00000690393.1 [Q13617-1] A0A8I5KU22 ENST00000688571.1 ENST00000688736.1 ENST00000691263.1 A0A8I5KVR3 ENST00000687524.1 ENST00000374748.5 [Q13617-1] A0A8I5KS98 A0A8I5KY75 ENST00000468804.6 A0A8I5QKN3 A0A8I5QJI3 A0A8I5KWB8 ENST00000691272.1 ENST00000691858.1 ENST00000374751.7 [Q13617-1] ENST00000688541.1 ENST00000690123.1 ENST00000673636.2 [Q13617-1] ENST00000686903.1 ENST00000537177.6 A0A8I5KUA9 ENST00000626172.3 A0A0A0MTN0 |