FBXO4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FBXO4 at tissue level.

III. Associated gene sets

GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_1902916Biological processpositive regulation of protein polyubiquitination
GO_0010608Biological processpost-transcriptional regulation of gene expression
GO_0031648Biological processprotein destabilization
GO_0019725Biological processcellular homeostasis
GO_0035726Biological processcommon myeloid progenitor cell proliferation
GO_0090398Biological processcellular senescence
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_1900181Biological processnegative regulation of protein localization to nucleus
GO_2000001Biological processregulation of DNA damage checkpoint
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0071479Biological processcellular response to ionizing radiation
GO_0031647Biological processregulation of protein stability
GO_0000151Cellular componentubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXO4
Protein nameF-box only protein 4
F-box protein 4
SynonymsFBX4
DescriptionFUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation . Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 . Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome . .

AccessionsENST00000296812.6 [Q9UKT5-2]
ENST00000513496.5
ENST00000281623.8 [Q9UKT5-1]
D6RAJ6
D6REP2
ENST00000509134.1
ENST00000504463.5
Q9UKT5
D6RAU6