ARIH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0039585Biological processPKR/eIFalpha signaling
GO_0000151Cellular componentubiquitin ligase complex
GO_0031464Cellular componentCul4A-RING E3 ubiquitin ligase complex
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0015030Cellular componentCajal body
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0097413Cellular componentLewy body
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019787Molecular functionubiquitin-like protein transferase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0031624Molecular functionubiquitin conjugating enzyme binding

IV. Literature review

[source]
Gene nameARIH1
Protein nameAriadne RBR E3 ubiquitin protein ligase 1
E3 ubiquitin-protein ligase ARIH1 (EC 2.3.2.31) (H7-AP2) (HHARI) (Monocyte protein 6) (MOP-6) (Protein ariadne-1 homolog) (ARI-1) (UbcH7-binding protein) (UbcM4-interacting protein) (Ubiquitin-conjugating enzyme E2-binding protein 1)
RBR-type E3 ubiquitin transferase (EC 2.3.2.31)
SynonymsMOP6
ARI
UBCH7BP
HUSSY-27
DescriptionFUNCTION: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 . Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets . The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 . E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes . Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear . According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest . According to another report EIF4E2 ubiquitination leads to its subsequent degradation . Acts as the ligase involved in ISGylation of EIF4E2 . In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology . .

AccessionsENST00000561770.1
H3BUS0
ENST00000562891.2
H3BNB9
ENST00000379887.9
Q9Y4X5
A0A087WT96
ENST00000564062.1
H3BSK4
ENST00000570085.5