Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 9 studies | 25% ± 6% | |
fibroblast | 8 studies | 19% ± 3% | |
plasma cell | 6 studies | 30% ± 9% | |
epithelial cell | 5 studies | 26% ± 7% | |
astrocyte | 4 studies | 26% ± 8% | |
microglial cell | 4 studies | 24% ± 6% | |
endothelial cell of lymphatic vessel | 4 studies | 20% ± 2% | |
macrophage | 4 studies | 21% ± 4% | |
cardiac muscle cell | 3 studies | 18% ± 1% | |
GABAergic neuron | 3 studies | 38% ± 13% | |
glutamatergic neuron | 3 studies | 45% ± 16% | |
oligodendrocyte precursor cell | 3 studies | 26% ± 6% | |
pericyte | 3 studies | 19% ± 3% | |
oligodendrocyte | 3 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3858.82 | 1445 / 1445 | 100% | 29.85 | 183 / 183 |
lung | 100% | 4408.23 | 578 / 578 | 100% | 27.83 | 1153 / 1155 |
stomach | 100% | 3356.09 | 359 / 359 | 100% | 25.69 | 285 / 286 |
breast | 100% | 4303.44 | 459 / 459 | 100% | 35.25 | 1114 / 1118 |
intestine | 100% | 4491.83 | 966 / 966 | 99% | 25.62 | 524 / 527 |
ovary | 100% | 4488.37 | 180 / 180 | 99% | 27.87 | 427 / 430 |
bladder | 100% | 4234.95 | 21 / 21 | 99% | 27.37 | 500 / 504 |
prostate | 100% | 4301.82 | 245 / 245 | 99% | 30.01 | 497 / 502 |
skin | 100% | 4653.77 | 1808 / 1809 | 99% | 28.74 | 467 / 472 |
pancreas | 100% | 1965.10 | 327 / 328 | 99% | 25.28 | 176 / 178 |
thymus | 100% | 4139.45 | 653 / 653 | 98% | 27.11 | 595 / 605 |
uterus | 100% | 5385.58 | 170 / 170 | 98% | 27.51 | 450 / 459 |
brain | 98% | 2104.05 | 2594 / 2642 | 99% | 24.93 | 699 / 705 |
kidney | 100% | 3288.54 | 89 / 89 | 97% | 22.34 | 876 / 901 |
adrenal gland | 100% | 5275.15 | 258 / 258 | 94% | 23.67 | 216 / 230 |
liver | 100% | 2162.61 | 226 / 226 | 90% | 14.76 | 366 / 406 |
adipose | 100% | 4189.54 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4513.19 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2671.09 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 5053.73 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 26.49 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.42 | 1 / 1 |
heart | 99% | 3957.64 | 852 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 26.54 | 79 / 80 |
peripheral blood | 95% | 2319.52 | 880 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 26.02 | 27 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032508 | Biological process | DNA duplex unwinding |
GO_0016567 | Biological process | protein ubiquitination |
GO_1902231 | Biological process | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
GO_0006281 | Biological process | DNA repair |
GO_0006308 | Biological process | DNA catabolic process |
GO_0006974 | Biological process | DNA damage response |
GO_0001934 | Biological process | positive regulation of protein phosphorylation |
GO_0000724 | Biological process | double-strand break repair via homologous recombination |
GO_0031297 | Biological process | replication fork processing |
GO_0072429 | Biological process | response to intra-S DNA damage checkpoint signaling |
GO_2000042 | Biological process | negative regulation of double-strand break repair via homologous recombination |
GO_0019005 | Cellular component | SCF ubiquitin ligase complex |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0003697 | Molecular function | single-stranded DNA binding |
GO_0003690 | Molecular function | double-stranded DNA binding |
GO_0003678 | Molecular function | DNA helicase activity |
GO_0015616 | Molecular function | DNA translocase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0016853 | Molecular function | isomerase activity |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
GO_0043138 | Molecular function | 3'-5' DNA helicase activity |
Gene name | FBH1 |
Protein name | DNA 3'-5' helicase (EC 5.6.2.4) F-box DNA helicase 1 (hFBH1) (EC 5.6.2.4) (DNA 3'-5' helicase 1) (F-box only protein 18) FBXO18 protein |
Synonyms | FBXO18 hCG_24070 FBX18 |
Description | FUNCTION: 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks . Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination . Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress . Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal . In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location . . |
Accessions | Q14DG0 Q2TAK1 ENST00000397269.7 Q66K33 A0JLR1 Q8NFZ0 F6UZG9 ENST00000362091.9 [Q8NFZ0-1] ENST00000379999.6 [Q8NFZ0-2] |