FBH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0016567Biological processprotein ubiquitination
GO_1902231Biological processpositive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO_0006281Biological processDNA repair
GO_0006308Biological processDNA catabolic process
GO_0006974Biological processDNA damage response
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0031297Biological processreplication fork processing
GO_0072429Biological processresponse to intra-S DNA damage checkpoint signaling
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0003678Molecular functionDNA helicase activity
GO_0015616Molecular functionDNA translocase activity
GO_0005524Molecular functionATP binding
GO_0016853Molecular functionisomerase activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0043138Molecular function3'-5' DNA helicase activity

IV. Literature review

[source]
Gene nameFBH1
Protein nameDNA 3'-5' helicase (EC 5.6.2.4)
F-box DNA helicase 1 (hFBH1) (EC 5.6.2.4) (DNA 3'-5' helicase 1) (F-box only protein 18)
FBXO18 protein
SynonymsFBXO18
hCG_24070
FBX18
DescriptionFUNCTION: 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks . Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination . Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress . Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal . In addition to the helicase activity, also acts as the substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location . .

AccessionsQ14DG0
Q2TAK1
ENST00000397269.7
Q66K33
A0JLR1
Q8NFZ0
F6UZG9
ENST00000362091.9 [Q8NFZ0-1]
ENST00000379999.6 [Q8NFZ0-2]