SPSB2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPSB2 at tissue level.

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0035556Biological processintracellular signal transduction
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPSB2
Protein nameSPRY domain-containing SOCS box protein 2 (SSB-2) (Gene-rich cluster protein C9)
SplA/ryanodine receptor domain and SOCS box containing 2
SynonymsGRCC9
SSB2
DescriptionFUNCTION: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 . Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 . .

AccessionsENST00000524270.6 [Q99619-1]
ENST00000432205.5
ENST00000523102.5 [Q99619-1]
ENST00000519357.1 [Q99619-2]
Q99619
E5RIC2