CCNF report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CCNF at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCNF at tissue level.

III. Associated gene sets

GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0000079Biological processregulation of cyclin-dependent protein serine/threonine kinase activity
GO_0051301Biological processcell division
GO_0001890Biological processplacenta development
GO_0010826Biological processnegative regulation of centrosome duplication
GO_0051726Biological processregulation of cell cycle
GO_0000320Biological processre-entry into mitotic cell cycle
GO_0044772Biological processmitotic cell cycle phase transition
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005813Cellular componentcentrosome
GO_0005814Cellular componentcentriole
GO_0000307Cellular componentcyclin-dependent protein kinase holoenzyme complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0030054Cellular componentcell junction
GO_0005634Cellular componentnucleus
GO_0016538Molecular functioncyclin-dependent protein serine/threonine kinase regulator activity
GO_0005515Molecular functionprotein binding
GO_0010997Molecular functionanaphase-promoting complex binding

IV. Literature review

[source]
Gene nameCCNF
Protein nameCyclin-F (F-box only protein 1)
Cyclin F
SynonymsFBX1
FBXO1
DescriptionFUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle . Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability . Mediates the ubiquitination and proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication . In G2, mediates the ubiquitination and subsequent degradation of ribonucleotide reductase RRM2, thereby maintaining a balanced pool of dNTPs and genome integrity . In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability . Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry . May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB . .

AccessionsH0Y2P7
P41002
H3BUD3
ENST00000293968.11
ENST00000397066.9
ENST00000564236.1