FBXL7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0051301Biological processcell division
GO_0000278Biological processmitotic cell cycle
GO_0000209Biological processprotein polyubiquitination
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0000151Cellular componentubiquitin ligase complex
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXL7
Protein nameAlternative protein FBXL7
F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7)
F-box and leucine rich repeat protein 7
SynonymsFBL7
KIAA0840
FBL6
DescriptionFUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex . During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (By similarity). It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 . .

AccessionsJ3KNM9
ENST00000510662.1 [Q9UJT9-2]
L8EAM2
Q9UJT9
ENST00000504595.2 [Q9UJT9-1]
ENST00000329673.8