FBXO9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0032006Biological processregulation of TOR signaling
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0045444Biological processfat cell differentiation
GO_0045087Biological processinnate immune response
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0000151Cellular componentubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXO9
Protein nameF-box protein 9
F-box only protein
F-box only protein 9 (Cross-immune reaction antigen 1) (Renal carcinoma antigen NY-REN-57)
SynonymsFBX9
VCIA1
DescriptionFUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability . Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1 . Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway . Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation (By similarity). .

FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation. .

AccessionsC9IY65
V9GZ74
ENST00000473318.1
ENST00000473337.6
ENST00000323557.12 [Q9UK97-2]
ENST00000244426.10 [Q9UK97-1]
C9J4V1
ENST00000459845.6
ENST00000370939.7 [Q9UK97-3]
Q9UK97
ENST00000498744.5
C9JDZ9
H7C4H6
ENST00000484436.7