FBXO45 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FBXO45 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0060386Biological processsynapse assembly involved in innervation
GO_0006974Biological processDNA damage response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0001764Biological processneuron migration
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0021960Biological processanterior commissure morphogenesis
GO_0021800Biological processcerebral cortex tangential migration
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0021957Biological processcorticospinal tract morphogenesis
GO_2000300Biological processregulation of synaptic vesicle exocytosis
GO_0021799Biological processcerebral cortex radially oriented cell migration
GO_0098978Cellular componentglutamatergic synapse
GO_0005576Cellular componentextracellular region
GO_0042734Cellular componentpresynaptic membrane
GO_0045202Cellular componentsynapse
GO_0014069Cellular componentpostsynaptic density
GO_0099524Cellular componentpostsynaptic cytosol
GO_0005737Cellular componentcytoplasm
GO_0045211Cellular componentpostsynaptic membrane
GO_0042995Cellular componentcell projection
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0099523Cellular componentpresynaptic cytosol
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXO45
Protein nameF-box/SPRY domain-containing protein 1 (F-box only protein 45) (hFbxo45)
F-box protein 45
SynonymsFBX45
DescriptionFUNCTION: Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1 . Functions in substrate recognition but plays also an important role in assembly of the complex . Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Regulates neuron migration during brain development through interaction with N-cadherin/CDH2 after secretion via a non-classical mechanism (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. Polyubiquitinates NMNAT2, an adenylyltransferase that acts as an axon maintenance factor, and regulates its stability and degradation by the proteasome . Acts also by ubiquitinating FBXW7 during prolonged mitotic arrest and promotes FBXW7 proteasomal degradation . Induces subsequently an increase in mitotic slippage and prevents mitotic cell death . In response to influenza infection, mediates interferon-lambda receptor IFNLR1 polyubiquitination and degradation through the ubiquitin-proteasome system by docking with its intracellular receptor domain . .

AccessionsENST00000311630.7
C9JLC0
P0C2W1
ENST00000440469.1