SPSB3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	28 studies	25% ± 7%	Explore
T cell	18 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	17 studies	23% ± 6%	Explore
CD8-positive, alpha-beta T cell	17 studies	24% ± 7%	Explore
regulatory T cell	16 studies	25% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	29% ± 9%	Explore
B cell	13 studies	22% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	28% ± 8%	Explore
mature NK T cell	12 studies	26% ± 6%	Explore
endothelial cell	12 studies	26% ± 10%	Explore
gamma-delta T cell	12 studies	27% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	22% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	21% ± 4%	Explore
fibroblast	11 studies	21% ± 3%	Explore
memory B cell	10 studies	20% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	23% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 7%	Explore
pericyte	10 studies	19% ± 4%	Explore
type I pneumocyte	10 studies	21% ± 5%	Explore
mucosal invariant T cell	9 studies	29% ± 4%	Explore
naive B cell	9 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	25% ± 6%	Explore
classical monocyte	7 studies	24% ± 9%	Explore
plasmacytoid dendritic cell	7 studies	23% ± 6%	Explore
epithelial cell	7 studies	31% ± 13%	Explore
non-classical monocyte	6 studies	27% ± 11%	Explore
abnormal cell	6 studies	19% ± 2%	Explore
basal cell	5 studies	31% ± 11%	Explore
exhausted T cell	5 studies	26% ± 8%	Explore
macrophage	5 studies	18% ± 3%	Explore
astrocyte	5 studies	25% ± 6%	Explore
T follicular helper cell	5 studies	23% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	21% ± 7%	Explore
conventional dendritic cell	4 studies	35% ± 17%	Explore
precursor B cell	4 studies	31% ± 7%	Explore
pro-B cell	4 studies	27% ± 8%	Explore
myofibroblast cell	4 studies	18% ± 1%	Explore
endothelial cell of lymphatic vessel	4 studies	20% ± 4%	Explore
retina horizontal cell	4 studies	26% ± 10%	Explore
ciliated cell	4 studies	27% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	27% ± 7%	Explore
innate lymphoid cell	4 studies	25% ± 3%	Explore
glutamatergic neuron	4 studies	33% ± 13%	Explore
oligodendrocyte precursor cell	4 studies	24% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	25% ± 2%	Explore
hematopoietic precursor cell	3 studies	26% ± 13%	Explore
secretory cell	3 studies	25% ± 5%	Explore
squamous epithelial cell	3 studies	35% ± 8%	Explore
leukocyte	3 studies	16% ± 1%	Explore
retinal bipolar neuron	3 studies	26% ± 6%	Explore
smooth muscle cell	3 studies	22% ± 3%	Explore
endothelial cell of vascular tree	3 studies	17% ± 2%	Explore
capillary endothelial cell	3 studies	21% ± 7%	Explore
immature B cell	3 studies	25% ± 4%	Explore
amacrine cell	3 studies	33% ± 10%	Explore
retinal rod cell	3 studies	21% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	21% ± 7%	Explore
adipocyte	3 studies	28% ± 6%	Explore
GABAergic neuron	3 studies	26% ± 7%	Explore
oligodendrocyte	3 studies	22% ± 5%	Explore
club cell	3 studies	18% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	36% ± 9%	Explore
goblet cell	3 studies	23% ± 3%	Explore
neuron	3 studies	33% ± 11%	Explore
double negative thymocyte	3 studies	30% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	24% ± 8%	Explore
lung	6 studies	23% ± 6%	Explore
eye	5 studies	23% ± 4%	Explore
brain	5 studies	25% ± 11%	Explore
lymph node	4 studies	19% ± 1%	Explore
kidney	3 studies	20% ± 2%	Explore
liver	3 studies	25% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	2011.11	258 / 258	14%	0.25	33 / 230
ovary	100%	1836.11	180 / 180	8%	0.11	34 / 430
thymus	100%	1766.91	653 / 653	7%	0.17	40 / 605
liver	100%	1276.79	226 / 226	3%	0.04	13 / 406
stomach	100%	1244.06	359 / 359	3%	0.05	9 / 286
esophagus	100%	1453.46	1445 / 1445	2%	0.03	3 / 183
intestine	100%	1488.97	966 / 966	2%	0.02	8 / 527
breast	100%	1688.34	459 / 459	1%	0.02	16 / 1118
bladder	100%	1329.05	21 / 21	1%	0.02	7 / 504
kidney	100%	1310.47	89 / 89	1%	0.01	10 / 901
prostate	100%	1863.12	245 / 245	1%	0.01	3 / 502
uterus	100%	1481.66	170 / 170	0%	0.00	1 / 459
adipose	100%	1414.00	1204 / 1204	0%	0	0 / 0
muscle	100%	1593.23	803 / 803	0%	0	0 / 0
pancreas	100%	1247.17	328 / 328	0%	0	0 / 178
peripheral blood	100%	1425.42	929 / 929	0%	0	0 / 0
spleen	100%	2133.40	241 / 241	0%	0	0 / 0
skin	100%	1623.11	1804 / 1809	0%	0.00	1 / 472
blood vessel	100%	1346.68	1334 / 1335	0%	0	0 / 0
lung	100%	1358.69	576 / 578	0%	0.01	3 / 1155
brain	98%	1101.24	2595 / 2642	1%	0.02	10 / 705
heart	98%	811.18	848 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0016567	Biological process	protein ubiquitination
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0019005	Cellular component	SCF ubiquitin ligase complex
GO_0005829	Cellular component	cytosol
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SPSB3
Protein name	SplA/ryanodine receptor domain and SOCS box containing 3, isoform CRA_c (cDNA FLJ25121 fis, clone CBR06051) SplA/ryanodine receptor domain and SOCS box containing 3 SPRY domain-containing SOCS box protein 3 (SSB-3)
Synonyms	C16orf31 SSB3 hCG_42718
Description	FUNCTION: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. .
Accessions	ENST00000566339.6 ENST00000569769.1 Q6PJ21 ENST00000301717.8 Q96LS6 H3BP12

SPSB3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review