FBXW11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0006470Biological processprotein dephosphorylation
GO_0000209Biological processprotein polyubiquitination
GO_0008090Biological processretrograde axonal transport
GO_0045862Biological processpositive regulation of proteolysis
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0031648Biological processprotein destabilization
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007281Biological processgerm cell development
GO_0042753Biological processpositive regulation of circadian rhythm
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0007097Biological processnuclear migration
GO_0048854Biological processbrain morphogenesis
GO_0016055Biological processWnt signaling pathway
GO_0031023Biological processmicrotubule organizing center organization
GO_0048511Biological processrhythmic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0047496Biological processvesicle transport along microtubule
GO_0000151Cellular componentubiquitin ligase complex
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0043025Cellular componentneuronal cell body
GO_0005635Cellular componentnuclear envelope
GO_0043005Cellular componentneuron projection
GO_0005829Cellular componentcytosol
GO_0005881Cellular componentcytoplasmic microtubule
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005875Cellular componentmicrotubule associated complex
GO_1904115Cellular componentaxon cytoplasm
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0051010Molecular functionmicrotubule plus-end binding
GO_0070840Molecular functiondynein complex binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXW11
Protein nameF-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
F-box and WD repeat domain containing 11
SynonymsFBW1B
KIAA0696
BTRCP2
FBXW1B
DescriptionFUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S . SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation . SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription . The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation . SCF(FBXW11) mediates the ubiquitination of IFNAR1 . SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis . Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1 . Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint . Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2 . SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 . SCF(FBXW11) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF . .; FUNCTION: (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. .

AccessionsENST00000393802.6 [Q9UKB1-2]
ENST00000265094.9 [Q9UKB1-1]
ENST00000523843.5
E5RGC1
E5RH92
ENST00000518752.1
ENST00000296933.10 [Q9UKB1-3]
ENST00000519693.5
ENST00000517395.6
E5RG78
ENST00000520376.1
Q9UKB1