FBXW7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903378Biological processpositive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_1901524Biological processregulation of mitophagy
GO_0007062Biological processsister chromatid cohesion
GO_0030324Biological processlung development
GO_0006281Biological processDNA repair
GO_1901800Biological processpositive regulation of proteasomal protein catabolic process
GO_0010868Biological processnegative regulation of triglyceride biosynthetic process
GO_0007219Biological processNotch signaling pathway
GO_2000639Biological processnegative regulation of SREBP signaling pathway
GO_0045741Biological processpositive regulation of epidermal growth factor-activated receptor activity
GO_0010629Biological processnegative regulation of gene expression
GO_2001205Biological processnegative regulation of osteoclast development
GO_0051443Biological processpositive regulation of ubiquitin-protein transferase activity
GO_0032880Biological processregulation of protein localization
GO_1902806Biological processregulation of cell cycle G1/S phase transition
GO_0001570Biological processvasculogenesis
GO_0031648Biological processprotein destabilization
GO_0010992Biological processubiquitin recycling
GO_0042752Biological processregulation of circadian rhythm
GO_0001944Biological processvasculature development
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0050821Biological processprotein stabilization
GO_2000346Biological processnegative regulation of hepatocyte proliferation
GO_0010883Biological processregulation of lipid storage
GO_0090049Biological processregulation of cell migration involved in sprouting angiogenesis
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0055088Biological processlipid homeostasis
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0048511Biological processrhythmic process
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005730Cellular componentnucleolus
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_1990452Cellular componentParkin-FBXW7-Cul1 ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005694Cellular componentchromosome
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0050816Molecular functionphosphothreonine residue binding
GO_0097027Molecular functionubiquitin-protein transferase activator activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding
GO_0030332Molecular functioncyclin binding

IV. Literature review

[source]
Gene nameFBXW7
Protein nameF-box and WD40 domain protein 7
F-box and WD repeat domain containing 7
F-box and WD repeat domain containing 7 (F-box and WD repeat domain containing 7 isoform 2) (F-box and WD repeat domain containing 7 isoform 3) (F-box and WD repeat domain containing 7 isoform 4) (F-box and WD repeat domain containing 7 isoform 5) (F-box and WD repeat domain containing 7 isoform 6) (F-box and WD repeat domain containing 7 isoform 7)
F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4)
SynonymsFBX30
SEL10
FBW7
DescriptionFUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination . Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1, MLST8, RICTOR, and probably PSEN1 . Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation . Involved in bone homeostasis and negative regulation of osteoclast differentiation . Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination . Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage . The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining . .

AccessionsQ969H0
H9CWI3
ENST00000703554.1
ENST00000643834.1
A7BJS8
S4R3U4
ENST00000603841.1 [Q969H0-1]
ENST00000604872.6
ENST00000642901.1
ENST00000703551.1
H9CWI2
A0A994J3P3
G0Z2K0
A0A994J3V4
ENST00000703552.1
ENST00000393956.9 [Q969H0-2]
ENST00000703555.1
ENST00000605042.1
S4R3N3
ENST00000647166.1
A0A994J6F2
ENST00000281708.10 [Q969H0-1]
ENST00000603548.6 [Q969H0-1]
A0A994J497
ENST00000296555.11 [Q969H0-4]
ENST00000703553.1
A0A994J6T8