Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 27 studies | 34% ± 14% | |
| plasma cell | 16 studies | 38% ± 21% | |
| glutamatergic neuron | 13 studies | 66% ± 23% | |
| astrocyte | 12 studies | 34% ± 15% | |
| microglial cell | 12 studies | 41% ± 9% | |
| B cell | 11 studies | 29% ± 11% | |
| GABAergic neuron | 11 studies | 43% ± 23% | |
| macrophage | 11 studies | 37% ± 13% | |
| oligodendrocyte | 11 studies | 30% ± 12% | |
| oligodendrocyte precursor cell | 10 studies | 33% ± 11% | |
| fibroblast | 10 studies | 28% ± 6% | |
| pericyte | 9 studies | 28% ± 7% | |
| T cell | 8 studies | 29% ± 8% | |
| neuron | 8 studies | 41% ± 18% | |
| amacrine cell | 8 studies | 38% ± 10% | |
| natural killer cell | 7 studies | 29% ± 9% | |
| interneuron | 7 studies | 44% ± 25% | |
| myeloid cell | 7 studies | 31% ± 7% | |
| adipocyte | 7 studies | 34% ± 7% | |
| dendritic cell | 7 studies | 39% ± 15% | |
| CD8-positive, alpha-beta T cell | 6 studies | 25% ± 6% | |
| epithelial cell | 6 studies | 39% ± 19% | |
| mast cell | 6 studies | 31% ± 11% | |
| ciliated cell | 6 studies | 26% ± 9% | |
| endothelial cell of lymphatic vessel | 6 studies | 32% ± 9% | |
| smooth muscle cell | 6 studies | 26% ± 6% | |
| classical monocyte | 5 studies | 26% ± 11% | |
| CD16-positive, CD56-dim natural killer cell, human | 5 studies | 22% ± 6% | |
| CD4-positive, alpha-beta T cell | 5 studies | 28% ± 7% | |
| effector memory CD8-positive, alpha-beta T cell | 5 studies | 24% ± 6% | |
| retinal bipolar neuron | 5 studies | 23% ± 6% | |
| cardiac muscle cell | 5 studies | 50% ± 14% | |
| Mueller cell | 5 studies | 34% ± 22% | |
| basal cell | 5 studies | 34% ± 23% | |
| monocyte | 5 studies | 46% ± 8% | |
| type I pneumocyte | 5 studies | 31% ± 8% | |
| type II pneumocyte | 5 studies | 29% ± 7% | |
| non-classical monocyte | 4 studies | 33% ± 11% | |
| plasmablast | 4 studies | 30% ± 10% | |
| granule cell | 4 studies | 44% ± 10% | |
| lymphocyte | 4 studies | 43% ± 16% | |
| retinal rod cell | 4 studies | 28% ± 5% | |
| regulatory T cell | 4 studies | 29% ± 9% | |
| club cell | 4 studies | 30% ± 8% | |
| CD16-negative, CD56-bright natural killer cell, human | 3 studies | 20% ± 2% | |
| mature NK T cell | 3 studies | 26% ± 10% | |
| naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 26% ± 7% | |
| IgG plasma cell | 3 studies | 29% ± 13% | |
| GABAergic interneuron | 3 studies | 34% ± 1% | |
| glial cell | 3 studies | 26% ± 5% | |
| retinal ganglion cell | 3 studies | 27% ± 1% | |
| pro-B cell | 3 studies | 23% ± 3% | |
| mesothelial cell | 3 studies | 25% ± 6% | |
| vein endothelial cell | 3 studies | 34% ± 17% | |
| GABAergic amacrine cell | 3 studies | 51% ± 7% | |
| OFF-bipolar cell | 3 studies | 23% ± 5% | |
| ON-bipolar cell | 3 studies | 25% ± 4% | |
| glycinergic amacrine cell | 3 studies | 56% ± 11% | |
| retinal cone cell | 3 studies | 21% ± 7% | |
| rod bipolar cell | 3 studies | 25% ± 6% | |
| CD8-positive, alpha-beta memory T cell | 3 studies | 19% ± 2% | |
| endothelial cell of vascular tree | 3 studies | 35% ± 20% | |
| hepatocyte | 3 studies | 56% ± 22% | |
| neural progenitor cell | 3 studies | 36% ± 22% | |
| alveolar macrophage | 3 studies | 41% ± 12% | |
| capillary endothelial cell | 3 studies | 26% ± 5% | |
| respiratory goblet cell | 3 studies | 32% ± 11% | |
| goblet cell | 3 studies | 37% ± 28% | |
| keratinocyte | 3 studies | 31% ± 10% | |
| mural cell | 3 studies | 42% ± 16% | |
| mucus secreting cell | 3 studies | 36% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1740.11 | 1443 / 1445 | 99% | 7.73 | 182 / 183 |
| breast | 100% | 2124.93 | 458 / 459 | 99% | 7.07 | 1111 / 1118 |
| uterus | 100% | 1581.40 | 170 / 170 | 99% | 6.49 | 455 / 459 |
| thymus | 99% | 1564.90 | 647 / 653 | 100% | 10.05 | 605 / 605 |
| lung | 99% | 2048.81 | 573 / 578 | 99% | 6.98 | 1148 / 1155 |
| bladder | 100% | 1389.38 | 21 / 21 | 98% | 5.82 | 496 / 504 |
| prostate | 100% | 1474.01 | 244 / 245 | 98% | 4.39 | 491 / 502 |
| stomach | 100% | 1488.36 | 359 / 359 | 97% | 5.39 | 278 / 286 |
| intestine | 100% | 1602.76 | 965 / 966 | 97% | 5.13 | 512 / 527 |
| brain | 96% | 4910.60 | 2541 / 2642 | 100% | 11.35 | 705 / 705 |
| pancreas | 96% | 1189.57 | 316 / 328 | 99% | 6.45 | 176 / 178 |
| skin | 100% | 6403.45 | 1806 / 1809 | 92% | 6.00 | 433 / 472 |
| adrenal gland | 93% | 1071.88 | 240 / 258 | 97% | 8.91 | 222 / 230 |
| kidney | 84% | 905.22 | 75 / 89 | 95% | 5.16 | 854 / 901 |
| ovary | 100% | 1322.47 | 180 / 180 | 77% | 2.76 | 332 / 430 |
| liver | 88% | 940.82 | 199 / 226 | 75% | 2.80 | 306 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 10.16 | 29 / 29 |
| spleen | 100% | 2887.34 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.27 | 1 / 1 |
| adipose | 100% | 1772.18 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 100% | 2470.97 | 800 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 98% | 1354.71 | 1307 / 1335 | 0% | 0 | 0 / 0 |
| heart | 96% | 2205.55 | 828 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 6.53 | 43 / 45 |
| eye | 0% | 0 | 0 / 0 | 64% | 2.99 | 51 / 80 |
| peripheral blood | 63% | 2092.64 | 581 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1903378 | Biological process | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| GO_0031146 | Biological process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_1901524 | Biological process | regulation of mitophagy |
| GO_0007062 | Biological process | sister chromatid cohesion |
| GO_0030324 | Biological process | lung development |
| GO_0006281 | Biological process | DNA repair |
| GO_1901800 | Biological process | positive regulation of proteasomal protein catabolic process |
| GO_0010868 | Biological process | negative regulation of triglyceride biosynthetic process |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_2000639 | Biological process | negative regulation of SREBP signaling pathway |
| GO_0045741 | Biological process | positive regulation of epidermal growth factor-activated receptor activity |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_2001205 | Biological process | negative regulation of osteoclast development |
| GO_0051443 | Biological process | positive regulation of ubiquitin-protein transferase activity |
| GO_0032880 | Biological process | regulation of protein localization |
| GO_1902806 | Biological process | regulation of cell cycle G1/S phase transition |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0031648 | Biological process | protein destabilization |
| GO_0010992 | Biological process | ubiquitin recycling |
| GO_0042752 | Biological process | regulation of circadian rhythm |
| GO_0001944 | Biological process | vasculature development |
| GO_2000060 | Biological process | positive regulation of ubiquitin-dependent protein catabolic process |
| GO_0050821 | Biological process | protein stabilization |
| GO_2000346 | Biological process | negative regulation of hepatocyte proliferation |
| GO_0010883 | Biological process | regulation of lipid storage |
| GO_0090049 | Biological process | regulation of cell migration involved in sprouting angiogenesis |
| GO_0031398 | Biological process | positive regulation of protein ubiquitination |
| GO_0055088 | Biological process | lipid homeostasis |
| GO_1903955 | Biological process | positive regulation of protein targeting to mitochondrion |
| GO_0045746 | Biological process | negative regulation of Notch signaling pathway |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0048511 | Biological process | rhythmic process |
| GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| GO_0005730 | Cellular component | nucleolus |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_1990452 | Cellular component | Parkin-FBXW7-Cul1 ubiquitin ligase complex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0019005 | Cellular component | SCF ubiquitin ligase complex |
| GO_0005694 | Cellular component | chromosome |
| GO_0005634 | Cellular component | nucleus |
| GO_1990756 | Molecular function | ubiquitin-like ligase-substrate adaptor activity |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
| GO_0050816 | Molecular function | phosphothreonine residue binding |
| GO_0097027 | Molecular function | ubiquitin-protein transferase activator activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0043130 | Molecular function | ubiquitin binding |
| GO_0030332 | Molecular function | cyclin binding |
| Gene name | FBXW7 |
| Protein name | F-box and WD40 domain protein 7 F-box and WD repeat domain containing 7 F-box and WD repeat domain containing 7 (F-box and WD repeat domain containing 7 isoform 2) (F-box and WD repeat domain containing 7 isoform 3) (F-box and WD repeat domain containing 7 isoform 4) (F-box and WD repeat domain containing 7 isoform 5) (F-box and WD repeat domain containing 7 isoform 6) (F-box and WD repeat domain containing 7 isoform 7) F-box/WD repeat-containing protein 7 (Archipelago homolog) (hAgo) (F-box and WD-40 domain-containing protein 7) (F-box protein FBX30) (SEL-10) (hCdc4) |
| Synonyms | FBX30 SEL10 FBW7 |
| Description | FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination . Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1, MLST8, RICTOR, and probably PSEN1 . Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation . Involved in bone homeostasis and negative regulation of osteoclast differentiation . Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination . Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage . The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining . . |
| Accessions | Q969H0 H9CWI3 ENST00000703554.1 ENST00000643834.1 A7BJS8 S4R3U4 ENST00000603841.1 [Q969H0-1] ENST00000604872.6 ENST00000642901.1 ENST00000703551.1 H9CWI2 A0A994J3P3 G0Z2K0 A0A994J3V4 ENST00000703552.1 ENST00000393956.9 [Q969H0-2] ENST00000703555.1 ENST00000605042.1 S4R3N3 ENST00000647166.1 A0A994J6F2 ENST00000281708.10 [Q969H0-1] ENST00000603548.6 [Q969H0-1] A0A994J497 ENST00000296555.11 [Q969H0-4] ENST00000703553.1 A0A994J6T8 |