Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 9 studies | 25% ± 9% | |
| retinal ganglion cell | 4 studies | 81% ± 21% | |
| epithelial cell | 3 studies | 23% ± 9% | |
| Mueller cell | 3 studies | 24% ± 7% | |
| basal cell | 3 studies | 27% ± 2% | |
| GABAergic neuron | 3 studies | 23% ± 3% |
Insufficient scRNA-seq data for expression of FBXO2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 10558.06 | 2641 / 2642 | 93% | 58.32 | 653 / 705 |
| pancreas | 99% | 3157.30 | 324 / 328 | 78% | 18.63 | 139 / 178 |
| adrenal gland | 77% | 1358.64 | 199 / 258 | 88% | 69.98 | 203 / 230 |
| liver | 46% | 688.00 | 103 / 226 | 81% | 36.13 | 327 / 406 |
| prostate | 60% | 852.17 | 148 / 245 | 59% | 7.62 | 294 / 502 |
| thymus | 17% | 195.45 | 108 / 653 | 94% | 42.32 | 569 / 605 |
| breast | 45% | 859.75 | 208 / 459 | 65% | 17.81 | 723 / 1118 |
| ureter | 0% | 0 | 0 / 0 | 100% | 29.20 | 1 / 1 |
| skin | 47% | 616.95 | 843 / 1809 | 44% | 9.55 | 208 / 472 |
| kidney | 48% | 803.82 | 43 / 89 | 34% | 9.48 | 310 / 901 |
| ovary | 1% | 16.46 | 2 / 180 | 72% | 24.01 | 311 / 430 |
| uterus | 5% | 53.41 | 8 / 170 | 62% | 26.21 | 285 / 459 |
| lymph node | 0% | 0 | 0 / 0 | 66% | 6.89 | 19 / 29 |
| lung | 7% | 92.03 | 41 / 578 | 58% | 16.62 | 671 / 1155 |
| tonsil | 0% | 0 | 0 / 0 | 64% | 18.26 | 29 / 45 |
| esophagus | 13% | 158.71 | 184 / 1445 | 50% | 13.42 | 91 / 183 |
| stomach | 9% | 113.28 | 33 / 359 | 47% | 12.85 | 133 / 286 |
| eye | 0% | 0 | 0 / 0 | 54% | 7.46 | 43 / 80 |
| bladder | 5% | 42.71 | 1 / 21 | 42% | 11.54 | 214 / 504 |
| intestine | 2% | 20.79 | 16 / 966 | 37% | 9.55 | 193 / 527 |
| blood vessel | 8% | 94.00 | 104 / 1335 | 0% | 0 | 0 / 0 |
| heart | 8% | 97.74 | 67 / 861 | 0% | 0 | 0 / 0 |
| adipose | 7% | 96.06 | 88 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 4% | 76.27 | 33 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 11.04 | 7 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| GO_0031146 | Biological process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0031396 | Biological process | regulation of protein ubiquitination |
| GO_0099576 | Biological process | regulation of protein catabolic process at postsynapse, modulating synaptic transmission |
| GO_0036211 | Biological process | protein modification process |
| GO_0006508 | Biological process | proteolysis |
| GO_0036503 | Biological process | ERAD pathway |
| GO_0006516 | Biological process | glycoprotein catabolic process |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0098890 | Cellular component | extrinsic component of postsynaptic membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0019005 | Cellular component | SCF ubiquitin ligase complex |
| GO_0061630 | Molecular function | ubiquitin protein ligase activity |
| GO_0001540 | Molecular function | amyloid-beta binding |
| GO_0030246 | Molecular function | carbohydrate binding |
| GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
| GO_0031249 | Molecular function | denatured protein binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | FBXO2 |
| Protein name | F-box only protein 2 F-box protein 2 |
| Synonyms | FBX2 |
| Description | FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity). . |
| Accessions | ENST00000642025.1 Q9UK22 R4GNH2 ENST00000354287.5 A0A286YF37 ENST00000465901.1 |
