I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 25% ± 8% | |
| glutamatergic neuron | 3 studies | 28% ± 10% | |
| dendritic cell | 3 studies | 26% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 25% ± 8% | |
| glutamatergic neuron | 3 studies | 28% ± 10% | |
| dendritic cell | 3 studies | 26% ± 4% |
Insufficient scRNA-seq data for expression of FBXL12 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1513.23 | 1445 / 1445 | 100% | 20.65 | 183 / 183 |
| lung | 100% | 1394.88 | 578 / 578 | 100% | 20.68 | 1155 / 1155 |
| ovary | 100% | 1791.22 | 180 / 180 | 100% | 28.29 | 430 / 430 |
| pancreas | 100% | 627.90 | 328 / 328 | 100% | 22.71 | 178 / 178 |
| skin | 100% | 1321.89 | 1809 / 1809 | 100% | 22.99 | 472 / 472 |
| stomach | 100% | 1088.02 | 359 / 359 | 100% | 23.10 | 286 / 286 |
| thymus | 100% | 1494.66 | 653 / 653 | 100% | 28.28 | 604 / 605 |
| kidney | 100% | 1193.08 | 89 / 89 | 100% | 18.05 | 899 / 901 |
| bladder | 100% | 1876.10 | 21 / 21 | 100% | 25.05 | 502 / 504 |
| prostate | 100% | 1663.78 | 245 / 245 | 100% | 18.55 | 500 / 502 |
| uterus | 100% | 1857.92 | 170 / 170 | 100% | 25.26 | 457 / 459 |
| breast | 100% | 1554.07 | 459 / 459 | 100% | 20.24 | 1113 / 1118 |
| intestine | 100% | 1688.05 | 966 / 966 | 99% | 23.84 | 523 / 527 |
| adrenal gland | 100% | 1102.03 | 258 / 258 | 99% | 17.06 | 227 / 230 |
| brain | 98% | 679.81 | 2598 / 2642 | 100% | 19.70 | 705 / 705 |
| liver | 100% | 932.64 | 226 / 226 | 98% | 13.95 | 397 / 406 |
| adipose | 100% | 1573.39 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1595.23 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 15.34 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 23.47 | 29 / 29 |
| spleen | 100% | 1454.69 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 20.21 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 15.13 | 1 / 1 |
| muscle | 100% | 804.22 | 801 / 803 | 0% | 0 | 0 / 0 |
| heart | 100% | 811.19 | 857 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 89% | 691.37 | 823 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0031146 | Biological process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0019005 | Cellular component | SCF ubiquitin ligase complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005515 | Molecular function | protein binding |
| Gene name | FBXL12 |
| Protein name | Alternative protein FBXL12 F-box and leucine rich repeat protein 12 F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12) |
| Synonyms | FBL12 |
| Description | FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia. . |
| Accessions | K7EK37 ENST00000586651.5 K7EQJ7 Q9NXK8 K7ELM5 ENST00000589438.1 ENST00000588922.5 K7ESL6 K7EPT3 L8E9B2 ENST00000586469.1 K7EIK3 ENST00000590808.1 ENST00000591009.1 [Q9NXK8-2] ENST00000592732.5 ENST00000585379.5 [Q9NXK8-2] K7EPN7 ENST00000247977.9 [Q9NXK8-1] ENST00000592067.1 ENST00000586073.1 K7EQY7 ENST00000590277.1 ENST00000589626.5 K7EIR3 |
