Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 33% ± 16% | |
astrocyte | 15 studies | 39% ± 19% | |
oligodendrocyte precursor cell | 13 studies | 47% ± 20% | |
glutamatergic neuron | 12 studies | 48% ± 26% | |
oligodendrocyte | 12 studies | 39% ± 13% | |
GABAergic neuron | 11 studies | 45% ± 23% | |
microglial cell | 11 studies | 29% ± 10% | |
adipocyte | 8 studies | 28% ± 8% | |
macrophage | 7 studies | 32% ± 11% | |
fibroblast | 7 studies | 27% ± 8% | |
neuron | 6 studies | 39% ± 16% | |
interneuron | 6 studies | 56% ± 21% | |
pericyte | 6 studies | 30% ± 12% | |
epithelial cell | 5 studies | 33% ± 19% | |
cardiac muscle cell | 5 studies | 38% ± 11% | |
endothelial cell of lymphatic vessel | 5 studies | 27% ± 6% | |
smooth muscle cell | 5 studies | 22% ± 5% | |
type I pneumocyte | 5 studies | 19% ± 5% | |
granule cell | 4 studies | 34% ± 10% | |
amacrine cell | 4 studies | 28% ± 9% | |
retinal cone cell | 4 studies | 40% ± 16% | |
retinal rod cell | 4 studies | 36% ± 7% | |
GABAergic interneuron | 3 studies | 40% ± 3% | |
mesothelial cell | 3 studies | 28% ± 7% | |
GABAergic amacrine cell | 3 studies | 29% ± 10% | |
Mueller cell | 3 studies | 29% ± 8% | |
glycinergic amacrine cell | 3 studies | 27% ± 7% | |
retina horizontal cell | 3 studies | 32% ± 9% | |
retinal ganglion cell | 3 studies | 33% ± 14% | |
rod bipolar cell | 3 studies | 39% ± 16% | |
hepatocyte | 3 studies | 34% ± 14% | |
ependymal cell | 3 studies | 40% ± 14% | |
T cell | 3 studies | 18% ± 1% | |
alveolar macrophage | 3 studies | 20% ± 5% | |
ciliated cell | 3 studies | 30% ± 9% | |
erythrocyte | 3 studies | 41% ± 14% | |
monocyte | 3 studies | 19% ± 1% | |
type II pneumocyte | 3 studies | 20% ± 5% | |
lymphocyte | 3 studies | 24% ± 5% | |
basal cell | 3 studies | 34% ± 24% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 100% | 2647.12 | 258 / 258 | 100% | 23.00 | 230 / 230 |
esophagus | 100% | 1924.70 | 1445 / 1445 | 100% | 13.51 | 183 / 183 |
prostate | 100% | 2534.24 | 245 / 245 | 100% | 23.45 | 502 / 502 |
brain | 100% | 3802.91 | 2641 / 2642 | 100% | 27.06 | 705 / 705 |
breast | 100% | 1522.32 | 459 / 459 | 100% | 29.36 | 1116 / 1118 |
thymus | 100% | 1675.58 | 653 / 653 | 100% | 15.86 | 602 / 605 |
bladder | 100% | 1953.19 | 21 / 21 | 99% | 11.69 | 501 / 504 |
lung | 99% | 1283.16 | 574 / 578 | 100% | 12.80 | 1154 / 1155 |
intestine | 100% | 1639.84 | 965 / 966 | 99% | 10.62 | 523 / 527 |
skin | 100% | 1879.46 | 1808 / 1809 | 99% | 13.45 | 468 / 472 |
pancreas | 99% | 1082.17 | 326 / 328 | 99% | 12.27 | 177 / 178 |
uterus | 100% | 1908.05 | 170 / 170 | 99% | 13.17 | 453 / 459 |
stomach | 100% | 1349.53 | 359 / 359 | 99% | 10.73 | 282 / 286 |
kidney | 100% | 1369.22 | 89 / 89 | 99% | 12.08 | 888 / 901 |
ovary | 100% | 2237.72 | 180 / 180 | 97% | 9.77 | 417 / 430 |
liver | 100% | 996.13 | 226 / 226 | 90% | 6.33 | 365 / 406 |
eye | 0% | 0 | 0 / 0 | 100% | 12.33 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 9.82 | 29 / 29 |
spleen | 100% | 1957.16 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 12.12 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.24 | 1 / 1 |
muscle | 100% | 1681.13 | 802 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1348.79 | 1333 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 1376.75 | 1201 / 1204 | 0% | 0 | 0 / 0 |
heart | 97% | 2018.63 | 839 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 46% | 490.76 | 428 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0031146 | Biological process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006470 | Biological process | protein dephosphorylation |
GO_0000209 | Biological process | protein polyubiquitination |
GO_0060444 | Biological process | branching involved in mammary gland duct morphogenesis |
GO_0033598 | Biological process | mammary gland epithelial cell proliferation |
GO_0045862 | Biological process | positive regulation of proteolysis |
GO_0050860 | Biological process | negative regulation of T cell receptor signaling pathway |
GO_0007165 | Biological process | signal transduction |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0045879 | Biological process | negative regulation of smoothened signaling pathway |
GO_0031648 | Biological process | protein destabilization |
GO_0043433 | Biological process | negative regulation of DNA-binding transcription factor activity |
GO_0042752 | Biological process | regulation of circadian rhythm |
GO_1904668 | Biological process | positive regulation of ubiquitin protein ligase activity |
GO_0070936 | Biological process | protein K48-linked ubiquitination |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0042753 | Biological process | positive regulation of circadian rhythm |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0038061 | Biological process | non-canonical NF-kappaB signal transduction |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0043122 | Biological process | regulation of canonical NF-kappaB signal transduction |
GO_0060828 | Biological process | regulation of canonical Wnt signaling pathway |
GO_0061136 | Biological process | regulation of proteasomal protein catabolic process |
GO_0048511 | Biological process | rhythmic process |
GO_0071407 | Biological process | cellular response to organic cyclic compound |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0051726 | Biological process | regulation of cell cycle |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0019005 | Cellular component | SCF ubiquitin ligase complex |
GO_1990756 | Molecular function | ubiquitin-like ligase-substrate adaptor activity |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0016874 | Molecular function | ligase activity |
GO_0008013 | Molecular function | beta-catenin binding |
GO_0045309 | Molecular function | protein phosphorylated amino acid binding |
GO_1990757 | Molecular function | ubiquitin ligase activator activity |
GO_0046983 | Molecular function | protein dimerization activity |
GO_0005515 | Molecular function | protein binding |
Gene name | BTRC |
Protein name | F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) Beta-transducin repeat containing isoform 3 Beta-transducin repeat containing E3 ubiquitin protein ligase (Beta-transducin repeat containing isoform 4) (Beta-transducin repeat containing, isoform CRA_b) (cDNA FLJ54002, highly similar to F-box/WD repeat protein 1A) Beta-transducin repeat containing isoform 1 F-box and WD-repeat protein 1B isoform 3 F-box and WD-repeat protein 1B isoform 2 Beta-transducin repeat containing isoform 2 Beta-transducin repeat containing E3 ubiquitin protein ligase |
Synonyms | FBXW1A BTRCP FBW1A hCG_1811016 |
Description | FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Recognizes and binds to phosphorylated target proteins . SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling . SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 . SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription . Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' . The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation . SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis . SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 . May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 . Mediates ubiquitination of REST, thereby leading to its proteasomal degradation . SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (By similarity). SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF . . |
Accessions | Q5T1W7 ENST00000393441.8 ENST00000408038.6 [Q9Y297-2] Q9Y297 Q86WI5 ENST00000370187.8 [Q9Y297-1] A0A0S2Z507 A0A0S2Z4Q5 ENST00000370183.2 Q86WI4 A0A0S2Z4P6 B7Z3H4 |