BTRC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0006470Biological processprotein dephosphorylation
GO_0000209Biological processprotein polyubiquitination
GO_0060444Biological processbranching involved in mammary gland duct morphogenesis
GO_0033598Biological processmammary gland epithelial cell proliferation
GO_0045862Biological processpositive regulation of proteolysis
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0007165Biological processsignal transduction
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0045879Biological processnegative regulation of smoothened signaling pathway
GO_0031648Biological processprotein destabilization
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0042752Biological processregulation of circadian rhythm
GO_1904668Biological processpositive regulation of ubiquitin protein ligase activity
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0042753Biological processpositive regulation of circadian rhythm
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0016055Biological processWnt signaling pathway
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0060828Biological processregulation of canonical Wnt signaling pathway
GO_0061136Biological processregulation of proteasomal protein catabolic process
GO_0048511Biological processrhythmic process
GO_0071407Biological processcellular response to organic cyclic compound
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0051726Biological processregulation of cell cycle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0016874Molecular functionligase activity
GO_0008013Molecular functionbeta-catenin binding
GO_0045309Molecular functionprotein phosphorylated amino acid binding
GO_1990757Molecular functionubiquitin ligase activator activity
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBTRC
Protein nameF-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Beta-transducin repeat containing isoform 3
Beta-transducin repeat containing E3 ubiquitin protein ligase (Beta-transducin repeat containing isoform 4) (Beta-transducin repeat containing, isoform CRA_b) (cDNA FLJ54002, highly similar to F-box/WD repeat protein 1A)
Beta-transducin repeat containing isoform 1
F-box and WD-repeat protein 1B isoform 3
F-box and WD-repeat protein 1B isoform 2
Beta-transducin repeat containing isoform 2
Beta-transducin repeat containing E3 ubiquitin protein ligase
SynonymsFBXW1A
BTRCP
FBW1A
hCG_1811016
DescriptionFUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Recognizes and binds to phosphorylated target proteins . SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling . SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 . SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription . Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' . The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation . SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis . SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 . May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 . Mediates ubiquitination of REST, thereby leading to its proteasomal degradation . SCF(BTRC) mediates the ubiquitination and subsequent proteasomal degradation of KLF4; thereby negatively regulating cell pluripotency maintenance and embryogenesis (By similarity). SCF(BTRC) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF . .

AccessionsQ5T1W7
ENST00000393441.8
ENST00000408038.6 [Q9Y297-2]
Q9Y297
Q86WI5
ENST00000370187.8 [Q9Y297-1]
A0A0S2Z507
A0A0S2Z4Q5
ENST00000370183.2
Q86WI4
A0A0S2Z4P6
B7Z3H4