FBXL21P report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FBXL21P at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FBXL21P at tissue level.

III. Associated gene sets

GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_0016567Biological processprotein ubiquitination
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0048511Biological processrhythmic process
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0000151Cellular componentubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0004842Molecular functionubiquitin-protein transferase activity

IV. Literature review

[source]
Gene nameFBXL21P
Protein nameFBXL21 protein
Putative F-box/LRR-repeat protein 21 (F-box and leucine-rich repeat protein 21) (F-box and leucine-rich repeat protein 3B) (F-box/LRR-repeat protein 3B)
SynonymsFBL3
FBXL3B
FBL21
FBXL3P
FBXL21
DescriptionFUNCTION: Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity). .

AccessionsQ3KPF8
Q9UKT6