FBXL15 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0016567Biological processprotein ubiquitination
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0009953Biological processdorsal/ventral pattern formation
GO_0030282Biological processbone mineralization
GO_0030513Biological processpositive regulation of BMP signaling pathway
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXL15
Protein nameF-box/LRR-repeat protein 15
F-box/LRR-repeat protein 15 (F-box only protein 37)
F-box and leucine rich repeat protein 15
SynonymsFBXO37
DescriptionFUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2. .

AccessionsA0A0C4DFV0
ENST00000369956
ENST00000457067.1
X6RHD7
X6RJB2
ENST00000425536.1
Q9H469
ENST00000432590.5
ENST00000369956.8
X6RCZ8
ENST00000440407.5
X6RGT4