FBXL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_0016567Biological processprotein ubiquitination
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0048511Biological processrhythmic process
GO_0031648Biological processprotein destabilization
GO_0042752Biological processregulation of circadian rhythm
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0000151Cellular componentubiquitin ligase complex
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXL3
Protein nameF-box and leucine rich repeat protein 3
F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A)
SynonymsFBL3A
FBXL3A
DescriptionFUNCTION: Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation . The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2 . Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex . .

AccessionsQ9UKT7
C9J0Y7
ENST00000417323.1
ENST00000355619.10