FBXW8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0060271Biological processcilium assembly
GO_0016567Biological processprotein ubiquitination
GO_0007030Biological processGolgi organization
GO_0008283Biological processcell population proliferation
GO_0050775Biological processpositive regulation of dendrite morphogenesis
GO_0060716Biological processlabyrinthine layer blood vessel development
GO_0005814Cellular componentcentriole
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0036064Cellular componentciliary basal body
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0031467Cellular componentCul7-RING ubiquitin ligase complex
GO_1990393Cellular component3M complex
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXW8
Protein nameF-box and WD repeat domain containing 8
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
SynonymsFBW6
FBXO29
FBXW6
FBW8
FBX29
DescriptionFUNCTION: Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain . Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) . The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation . Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions . .

AccessionsENST00000455858.2 [Q8N3Y1-2]
ENST00000309909.10
ENST00000652555.1 [Q8N3Y1-1]
A0A499FIY5
Q8N3Y1