SPSB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0016567Biological processprotein ubiquitination
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPSB1
Protein nameSPRY domain-containing SOCS box protein 1 (SSB-1)
SplA/ryanodine receptor domain and SOCS box containing 1
SynonymsSSB1
DescriptionFUNCTION: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 . Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 . .

AccessionsA2A276
ENST00000377399.2
ENST00000328089.11
Q96BD6
ENST00000450402.1
ENST00000357898.3