FBXO7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903599Biological processpositive regulation of autophagy of mitochondrion
GO_0016567Biological processprotein ubiquitination
GO_1903377Biological processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO_0045620Biological processnegative regulation of lymphocyte differentiation
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0030098Biological processlymphocyte differentiation
GO_0040012Biological processregulation of locomotion
GO_1901526Biological processpositive regulation of mitophagy
GO_0010975Biological processregulation of neuron projection development
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0000422Biological processautophagy of mitochondrion
GO_0006626Biological processprotein targeting to mitochondrion
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0031647Biological processregulation of protein stability
GO_0000151Cellular componentubiquitin ligase complex
GO_0097414Cellular componentclassical Lewy body
GO_0005739Cellular componentmitochondrion
GO_1990038Cellular componentLewy body corona
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0097409Cellular componentglial cytoplasmic inclusion
GO_1990037Cellular componentLewy body core
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0097462Cellular componentLewy neurite
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0043130Molecular functionubiquitin binding
GO_0019901Molecular functionprotein kinase binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXO7
Protein nameF-box protein 7
F-box only protein 7
SynonymsFBX7
DescriptionFUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability . Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5 . Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway . Inhibits NF-kappa-B pathway also by promoting the ubiquitination of TRAF2 . Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains (By similarity). Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death . .

AccessionsENST00000452138.3 [Q9Y3I1-2]
ENST00000425028.5
ENST00000397426.5 [Q9Y3I1-3]
Q9Y3I1
ENST00000420700.5
F8WDR9
F8WBR0
ENST00000266087.12 [Q9Y3I1-1]
ENST00000444207.1
A2A282