FBXW5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007088Biological processregulation of mitotic nuclear division
GO_0016567Biological processprotein ubiquitination
GO_0031146Biological processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO_0010824Biological processregulation of centrosome duplication
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0019005Cellular componentSCF ubiquitin ligase complex
GO_0005829Cellular componentcytosol
GO_0080008Cellular componentCul4-RING E3 ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0019901Molecular functionprotein kinase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFBXW5
Protein nameF-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)
F-box and WD repeat domain containing 5
SynonymsFBW5
PP3971
DescriptionFUNCTION: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. .

AccessionsENST00000443788.1
ENST00000428398.5
Q969U6
ENST00000487794.5
A0A096LP04
A0A0A0MSV8
A0A096LNM2
ENST00000325285.8 [Q969U6-1]
A0A0A0MSK7
ENST00000491246.4