Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 10 studies | 54% ± 22% | |
GABAergic neuron | 8 studies | 46% ± 22% | |
endothelial cell | 8 studies | 30% ± 15% | |
ciliated cell | 8 studies | 35% ± 17% | |
oligodendrocyte precursor cell | 7 studies | 29% ± 11% | |
neuron | 6 studies | 38% ± 15% | |
interneuron | 6 studies | 49% ± 21% | |
epithelial cell | 5 studies | 25% ± 7% | |
type I pneumocyte | 5 studies | 30% ± 8% | |
retinal ganglion cell | 4 studies | 33% ± 9% | |
amacrine cell | 4 studies | 21% ± 3% | |
retina horizontal cell | 4 studies | 20% ± 3% | |
retinal rod cell | 4 studies | 21% ± 2% | |
adipocyte | 4 studies | 21% ± 4% | |
endothelial cell of lymphatic vessel | 4 studies | 20% ± 2% | |
astrocyte | 4 studies | 34% ± 15% | |
GABAergic interneuron | 3 studies | 38% ± 15% | |
GABAergic amacrine cell | 3 studies | 24% ± 3% | |
retinal cone cell | 3 studies | 24% ± 5% | |
type II pneumocyte | 3 studies | 18% ± 2% | |
fibroblast | 3 studies | 21% ± 8% | |
smooth muscle cell | 3 studies | 23% ± 5% | |
oligodendrocyte | 3 studies | 31% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 99% | 867.00 | 179 / 180 | 99% | 5.67 | 426 / 430 |
adrenal gland | 99% | 575.35 | 256 / 258 | 99% | 9.74 | 228 / 230 |
thymus | 100% | 1460.69 | 653 / 653 | 98% | 9.11 | 593 / 605 |
kidney | 100% | 805.20 | 89 / 89 | 98% | 5.60 | 882 / 901 |
breast | 99% | 585.12 | 453 / 459 | 99% | 6.67 | 1108 / 1118 |
brain | 99% | 1736.03 | 2607 / 2642 | 96% | 6.28 | 680 / 705 |
lung | 98% | 533.29 | 569 / 578 | 92% | 3.20 | 1064 / 1155 |
bladder | 100% | 538.19 | 21 / 21 | 74% | 2.34 | 373 / 504 |
prostate | 99% | 800.27 | 243 / 245 | 75% | 1.91 | 375 / 502 |
uterus | 99% | 883.79 | 168 / 170 | 75% | 3.01 | 342 / 459 |
skin | 70% | 305.55 | 1271 / 1809 | 95% | 4.45 | 447 / 472 |
esophagus | 80% | 520.84 | 1156 / 1445 | 84% | 2.41 | 154 / 183 |
pancreas | 61% | 201.61 | 201 / 328 | 95% | 5.01 | 169 / 178 |
intestine | 72% | 544.95 | 700 / 966 | 57% | 1.49 | 302 / 527 |
stomach | 56% | 321.87 | 202 / 359 | 59% | 1.53 | 170 / 286 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.17 | 1 / 1 |
blood vessel | 100% | 1829.38 | 1333 / 1335 | 0% | 0 | 0 / 0 |
adipose | 94% | 498.65 | 1134 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 90% | 3.14 | 72 / 80 |
tonsil | 0% | 0 | 0 / 0 | 62% | 1.33 | 28 / 45 |
heart | 51% | 195.03 | 437 / 861 | 0% | 0 | 0 / 0 |
spleen | 28% | 80.89 | 67 / 241 | 0% | 0 | 0 / 0 |
liver | 0% | 0.99 | 1 / 226 | 18% | 0.60 | 72 / 406 |
lymph node | 0% | 0 | 0 / 0 | 14% | 0.16 | 4 / 29 |
muscle | 1% | 4.39 | 12 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0.23 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0051896 | Biological process | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0016567 | Biological process | protein ubiquitination |
GO_0031146 | Biological process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
GO_0006513 | Biological process | protein monoubiquitination |
GO_0010506 | Biological process | regulation of autophagy |
GO_0036211 | Biological process | protein modification process |
GO_0050727 | Biological process | regulation of inflammatory response |
GO_0006508 | Biological process | proteolysis |
GO_0044830 | Biological process | modulation by host of viral RNA genome replication |
GO_1900226 | Biological process | negative regulation of NLRP3 inflammasome complex assembly |
GO_0019005 | Cellular component | SCF ubiquitin ligase complex |
GO_0016020 | Cellular component | membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_1990756 | Molecular function | ubiquitin-like ligase-substrate adaptor activity |
GO_0036312 | Molecular function | phosphatidylinositol 3-kinase regulatory subunit binding |
GO_0005516 | Molecular function | calmodulin binding |
GO_0005515 | Molecular function | protein binding |
GO_0019903 | Molecular function | protein phosphatase binding |
Gene name | FBXL2 |
Protein name | F-box and leucine rich repeat protein 2 F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3) |
Synonyms | FBL2 FBL3 |
Description | FUNCTION: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins . Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin . This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin . Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) . SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy . PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity). The SCF(FBXL2) complex acts as a regulator of inflammation by mediating ubiquitination and degradation of TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5 and TRAF6) (By similarity). The SCF(FBXL2) complex acts as a negative regulator of the NLRP3 inflammasome by mediating ubiquitination and degradation of NLRP3 . . |
Accessions | F8WCQ8 ENST00000435207.5 ENST00000451636.5 ENST00000484457.6 [Q9UKC9-1] ENST00000422741.5 ENST00000425973.5 Q9UKC9 F8WC58 ENST00000421391.5 F8WBS9 ENST00000432809.5 F8WE99 F8WB01 F8WBW7 |