USP47 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	28 studies	33% ± 15%	Explore
fibroblast	25 studies	30% ± 14%	Explore
natural killer cell	21 studies	22% ± 7%	Explore
astrocyte	19 studies	39% ± 18%	Explore
smooth muscle cell	18 studies	28% ± 10%	Explore
pericyte	18 studies	31% ± 16%	Explore
oligodendrocyte	16 studies	51% ± 18%	Explore
oligodendrocyte precursor cell	15 studies	41% ± 19%	Explore
microglial cell	13 studies	36% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	24% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	22% ± 4%	Explore
T cell	11 studies	25% ± 8%	Explore
GABAergic neuron	11 studies	45% ± 22%	Explore
glutamatergic neuron	11 studies	49% ± 24%	Explore
epithelial cell	11 studies	38% ± 21%	Explore
macrophage	11 studies	33% ± 13%	Explore
regulatory T cell	11 studies	21% ± 5%	Explore
CD4-positive, alpha-beta T cell	10 studies	22% ± 5%	Explore
CD8-positive, alpha-beta T cell	10 studies	21% ± 4%	Explore
basal cell	10 studies	32% ± 18%	Explore
type I pneumocyte	9 studies	29% ± 12%	Explore
adipocyte	9 studies	42% ± 12%	Explore
B cell	8 studies	24% ± 7%	Explore
neuron	8 studies	41% ± 20%	Explore
mucosal invariant T cell	8 studies	20% ± 3%	Explore
gamma-delta T cell	8 studies	22% ± 9%	Explore
naive B cell	7 studies	18% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	21% ± 4%	Explore
myofibroblast cell	7 studies	26% ± 11%	Explore
amacrine cell	7 studies	29% ± 8%	Explore
mast cell	7 studies	30% ± 8%	Explore
ciliated cell	7 studies	28% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	21% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	23% ± 2%	Explore
mature NK T cell	6 studies	22% ± 7%	Explore
interneuron	6 studies	58% ± 23%	Explore
connective tissue cell	6 studies	25% ± 10%	Explore
myeloid cell	6 studies	25% ± 4%	Explore
club cell	6 studies	30% ± 11%	Explore
retina horizontal cell	6 studies	29% ± 12%	Explore
Mueller cell	6 studies	40% ± 19%	Explore
type II pneumocyte	6 studies	34% ± 9%	Explore
classical monocyte	5 studies	21% ± 6%	Explore
leukocyte	5 studies	24% ± 9%	Explore
cardiac muscle cell	5 studies	43% ± 12%	Explore
dendritic cell	5 studies	29% ± 9%	Explore
endothelial cell of lymphatic vessel	5 studies	37% ± 10%	Explore
monocyte	5 studies	29% ± 6%	Explore
goblet cell	5 studies	34% ± 29%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	21% ± 4%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	36% ± 13%	Explore
granule cell	4 studies	40% ± 5%	Explore
progenitor cell	4 studies	30% ± 7%	Explore
retinal ganglion cell	4 studies	38% ± 13%	Explore
retinal bipolar neuron	4 studies	23% ± 4%	Explore
retinal cone cell	4 studies	24% ± 7%	Explore
endothelial cell of artery	4 studies	19% ± 5%	Explore
mesothelial cell	4 studies	34% ± 8%	Explore
lymphocyte	4 studies	41% ± 14%	Explore
retinal rod cell	4 studies	23% ± 4%	Explore
respiratory goblet cell	4 studies	30% ± 13%	Explore
muscle cell	4 studies	35% ± 22%	Explore
ionocyte	3 studies	21% ± 4%	Explore
hematopoietic precursor cell	3 studies	30% ± 12%	Explore
non-classical monocyte	3 studies	23% ± 5%	Explore
neural crest cell	3 studies	19% ± 2%	Explore
GABAergic interneuron	3 studies	41% ± 1%	Explore
glial cell	3 studies	37% ± 5%	Explore
plasma cell	3 studies	30% ± 4%	Explore
retinal pigment epithelial cell	3 studies	40% ± 27%	Explore
vein endothelial cell	3 studies	32% ± 18%	Explore
GABAergic amacrine cell	3 studies	41% ± 9%	Explore
OFF-bipolar cell	3 studies	32% ± 9%	Explore
ON-bipolar cell	3 studies	29% ± 8%	Explore
glycinergic amacrine cell	3 studies	30% ± 5%	Explore
rod bipolar cell	3 studies	28% ± 9%	Explore
innate lymphoid cell	3 studies	21% ± 3%	Explore
memory B cell	3 studies	16% ± 1%	Explore
endothelial cell of vascular tree	3 studies	32% ± 18%	Explore
hepatocyte	3 studies	62% ± 19%	Explore
ependymal cell	3 studies	46% ± 18%	Explore
enteroendocrine cell	3 studies	25% ± 8%	Explore
adventitial cell	3 studies	24% ± 7%	Explore
alveolar macrophage	3 studies	31% ± 10%	Explore
capillary endothelial cell	3 studies	22% ± 5%	Explore
chondrocyte	3 studies	33% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 8%	Explore
Schwann cell	3 studies	33% ± 21%	Explore
transit amplifying cell	3 studies	39% ± 31%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	20% ± 2%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	20% ± 2%	Explore
mural cell	3 studies	39% ± 13%	Explore
mucus secreting cell	3 studies	27% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	44% ± 22%	Explore
lung	11 studies	23% ± 8%	Explore
eye	8 studies	31% ± 18%	Explore
peripheral blood	6 studies	21% ± 4%	Explore
liver	5 studies	30% ± 14%	Explore
heart	4 studies	34% ± 8%	Explore
adipose	4 studies	30% ± 9%	Explore
intestine	3 studies	22% ± 6%	Explore
kidney	3 studies	25% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6769.93	1445 / 1445	100%	16.02	183 / 183
pancreas	100%	3551.25	328 / 328	99%	11.85	176 / 178
breast	100%	5561.51	459 / 459	99%	19.81	1104 / 1118
lung	100%	7219.61	578 / 578	98%	12.78	1136 / 1155
brain	100%	7589.12	2641 / 2642	98%	18.36	693 / 705
prostate	100%	7038.91	245 / 245	98%	16.47	491 / 502
stomach	100%	5242.76	359 / 359	97%	10.78	277 / 286
bladder	100%	6904.05	21 / 21	97%	10.87	487 / 504
thymus	100%	5607.93	653 / 653	96%	13.03	582 / 605
intestine	100%	6937.43	966 / 966	96%	10.17	505 / 527
uterus	100%	6986.91	170 / 170	95%	10.32	435 / 459
skin	100%	6305.53	1809 / 1809	93%	14.51	441 / 472
kidney	100%	3649.09	89 / 89	93%	10.38	840 / 901
liver	100%	3916.69	226 / 226	88%	8.20	357 / 406
adrenal gland	100%	5506.65	258 / 258	86%	8.74	197 / 230
ovary	100%	6086.74	180 / 180	75%	4.73	324 / 430
blood vessel	100%	8565.59	1335 / 1335	0%	0	0 / 0
muscle	100%	12266.85	803 / 803	0%	0	0 / 0
spleen	100%	4827.23	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.19	1 / 1
adipose	100%	5489.56	1203 / 1204	0%	0	0 / 0
heart	98%	7663.02	843 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	11.00	43 / 45
lymph node	0%	0	0 / 0	90%	9.15	26 / 29
eye	0%	0	0 / 0	73%	5.93	58 / 80
peripheral blood	60%	2045.91	557 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043154	Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0030307	Biological process	positive regulation of cell growth
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0034644	Biological process	cellular response to UV
GO_0006974	Biological process	DNA damage response
GO_0035520	Biological process	monoubiquitinated protein deubiquitination
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0006508	Biological process	proteolysis
GO_0008630	Biological process	intrinsic apoptotic signaling pathway in response to DNA damage
GO_1902230	Biological process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO_0016579	Biological process	protein deubiquitination
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0006284	Biological process	base-excision repair
GO_0010972	Biological process	negative regulation of G2/M transition of mitotic cell cycle
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0019005	Cellular component	SCF ubiquitin ligase complex
GO_0005634	Cellular component	nucleus
GO_0101005	Molecular function	deubiquitinase activity
GO_0004843	Molecular function	cysteine-type deubiquitinase activity
GO_0071987	Molecular function	WD40-repeat domain binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	USP47
Protein name	USP47 protein Ubiquitin carboxyl-terminal hydrolase 47 (EC 3.4.19.12) (Deubiquitinating enzyme 47) (Ubiquitin thioesterase 47) (Ubiquitin-specific-processing protease 47)
Synonyms
Description	FUNCTION: Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. .
Accessions	ENST00000339865.9 [Q96K76-2] ENST00000399455.2 [Q96K76-1] Q96K76 A0PJ80 ENST00000527733.7 [Q96K76-4]

USP47 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review