Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 24 studies | 29% ± 10% | |
| endothelial cell of artery | 12 studies | 48% ± 17% | |
| capillary endothelial cell | 11 studies | 23% ± 9% | |
| endothelial cell of vascular tree | 11 studies | 36% ± 16% | |
| vein endothelial cell | 3 studies | 22% ± 8% | |
| ciliated cell | 3 studies | 45% ± 31% | |
| secretory cell | 3 studies | 24% ± 2% |
Insufficient scRNA-seq data for expression of SOX17 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 51% | 375.37 | 92 / 180 | 99% | 288.89 | 425 / 430 |
| uterus | 98% | 1821.74 | 167 / 170 | 18% | 40.75 | 84 / 459 |
| breast | 100% | 3535.42 | 459 / 459 | 8% | 1.64 | 93 / 1118 |
| thymus | 93% | 673.53 | 607 / 653 | 11% | 1.97 | 65 / 605 |
| lung | 98% | 1093.78 | 566 / 578 | 3% | 0.62 | 33 / 1155 |
| spleen | 100% | 1445.70 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 100% | 4093.48 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| heart | 95% | 858.94 | 818 / 861 | 0% | 0 | 0 / 0 |
| prostate | 84% | 661.52 | 207 / 245 | 9% | 1.60 | 46 / 502 |
| bladder | 90% | 916.24 | 19 / 21 | 2% | 0.42 | 10 / 504 |
| muscle | 82% | 599.78 | 656 / 803 | 0% | 0 | 0 / 0 |
| esophagus | 77% | 799.80 | 1116 / 1445 | 3% | 0.45 | 5 / 183 |
| intestine | 76% | 693.16 | 730 / 966 | 2% | 0.35 | 9 / 527 |
| blood vessel | 77% | 755.87 | 1026 / 1335 | 0% | 0 | 0 / 0 |
| kidney | 44% | 236.24 | 39 / 89 | 23% | 4.25 | 211 / 901 |
| stomach | 56% | 461.57 | 202 / 359 | 6% | 1.09 | 18 / 286 |
| skin | 54% | 355.38 | 972 / 1809 | 1% | 0.34 | 6 / 472 |
| adrenal gland | 15% | 68.48 | 38 / 258 | 19% | 3.43 | 43 / 230 |
| brain | 18% | 63.48 | 475 / 2642 | 1% | 0.25 | 10 / 705 |
| pancreas | 6% | 25.29 | 21 / 328 | 8% | 1.36 | 15 / 178 |
| liver | 3% | 13.07 | 7 / 226 | 2% | 0.23 | 7 / 406 |
| peripheral blood | 0% | 1.32 | 4 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0001525 | Biological process | angiogenesis |
| GO_0060914 | Biological process | heart formation |
| GO_0003151 | Biological process | outflow tract morphogenesis |
| GO_0007283 | Biological process | spermatogenesis |
| GO_0045995 | Biological process | regulation of embryonic development |
| GO_0007507 | Biological process | heart development |
| GO_0001947 | Biological process | heart looping |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0061010 | Biological process | gallbladder development |
| GO_0001656 | Biological process | metanephros development |
| GO_0007493 | Biological process | endodermal cell fate determination |
| GO_0061031 | Biological process | endodermal digestive tract morphogenesis |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_1990830 | Biological process | cellular response to leukemia inhibitory factor |
| GO_0061009 | Biological process | common bile duct development |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0031648 | Biological process | protein destabilization |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_2000043 | Biological process | regulation of cardiac cell fate specification |
| GO_0048866 | Biological process | stem cell fate specification |
| GO_0060956 | Biological process | endocardial cell differentiation |
| GO_0060214 | Biological process | endocardium formation |
| GO_0023019 | Biological process | signal transduction involved in regulation of gene expression |
| GO_0045732 | Biological process | positive regulation of protein catabolic process |
| GO_0072091 | Biological process | regulation of stem cell proliferation |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0021903 | Biological process | rostrocaudal neural tube patterning |
| GO_0050821 | Biological process | protein stabilization |
| GO_2000035 | Biological process | regulation of stem cell division |
| GO_0035050 | Biological process | embryonic heart tube development |
| GO_0042074 | Biological process | cell migration involved in gastrulation |
| GO_0060913 | Biological process | cardiac cell fate determination |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0072189 | Biological process | ureter development |
| GO_0003143 | Biological process | embryonic heart tube morphogenesis |
| GO_0001706 | Biological process | endoderm formation |
| GO_1903226 | Biological process | positive regulation of endodermal cell differentiation |
| GO_0010467 | Biological process | gene expression |
| GO_0016055 | Biological process | Wnt signaling pathway |
| GO_2000738 | Biological process | positive regulation of stem cell differentiation |
| GO_0001828 | Biological process | inner cell mass cellular morphogenesis |
| GO_0003142 | Biological process | cardiogenic plate morphogenesis |
| GO_0048617 | Biological process | embryonic foregut morphogenesis |
| GO_0001714 | Biological process | endodermal cell fate specification |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0030308 | Biological process | negative regulation of cell growth |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0008013 | Molecular function | beta-catenin binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SOX17 |
| Protein name | Transcription factor SOX-17 SOX17 protein |
| Synonyms | |
| Description | FUNCTION: Acts as a transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells. . |
| Accessions | Q9H6I2 ENST00000297316.5 Q2T9L5 Q2NKK5 |
