SOX2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	17 studies	38% ± 20%	Explore
ciliated cell	13 studies	37% ± 14%	Explore
basal cell	10 studies	37% ± 16%	Explore
oligodendrocyte precursor cell	10 studies	32% ± 13%	Explore
club cell	6 studies	30% ± 11%	Explore
deuterosomal cell	4 studies	27% ± 10%	Explore
respiratory goblet cell	4 studies	32% ± 5%	Explore
secretory cell	4 studies	41% ± 14%	Explore
Mueller cell	4 studies	58% ± 12%	Explore
duct epithelial cell	3 studies	21% ± 7%	Explore
epithelial cell	3 studies	29% ± 10%	Explore
glial cell	3 studies	35% ± 18%	Explore
neural progenitor cell	3 studies	36% ± 8%	Explore
oligodendrocyte	3 studies	31% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	22% ± 5%	Explore
lung	3 studies	32% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	4608.59	2631 / 2642	99%	621.01	699 / 705
esophagus	48%	1044.16	690 / 1445	42%	86.96	76 / 183
tonsil	0%	0	0 / 0	89%	158.21	40 / 45
stomach	70%	511.65	251 / 359	8%	8.60	24 / 286
lung	9%	82.86	50 / 578	47%	134.20	541 / 1155
intestine	42%	347.58	407 / 966	6%	7.02	34 / 527
uterus	2%	8.53	3 / 170	45%	79.67	207 / 459
prostate	26%	161.97	63 / 245	0%	0.21	2 / 502
bladder	5%	37.38	1 / 21	14%	27.01	72 / 504
skin	0%	0.90	3 / 1809	15%	10.80	69 / 472
ovary	0%	0	0 / 180	9%	9.53	37 / 430
breast	0%	1.86	1 / 459	2%	1.60	26 / 1118
blood vessel	2%	14.99	29 / 1335	0%	0	0 / 0
adrenal gland	0%	1.59	1 / 258	1%	0.61	3 / 230
thymus	0%	0	0 / 653	2%	1.22	10 / 605
eye	0%	0	0 / 0	1%	0.61	1 / 80
pancreas	0%	0	0 / 328	1%	0.52	2 / 178
adipose	1%	3.92	8 / 1204	0%	0	0 / 0
liver	0%	0	0 / 226	0%	0.65	2 / 406
kidney	0%	0	0 / 89	0%	0.41	2 / 901
peripheral blood	0%	0.78	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0010468	Biological process	regulation of gene expression
GO_0021984	Biological process	adenohypophysis development
GO_0097150	Biological process	neuronal stem cell population maintenance
GO_1902807	Biological process	negative regulation of cell cycle G1/S phase transition
GO_0001649	Biological process	osteoblast differentiation
GO_0030900	Biological process	forebrain development
GO_0048839	Biological process	inner ear development
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0042246	Biological process	tissue regeneration
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0050680	Biological process	negative regulation of epithelial cell proliferation
GO_0001654	Biological process	eye development
GO_0030182	Biological process	neuron differentiation
GO_0045597	Biological process	positive regulation of cell differentiation
GO_0045665	Biological process	negative regulation of neuron differentiation
GO_0043281	Biological process	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0021781	Biological process	glial cell fate commitment
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0007420	Biological process	brain development
GO_0022409	Biological process	positive regulation of cell-cell adhesion
GO_0090649	Biological process	response to oxygen-glucose deprivation
GO_0021983	Biological process	pituitary gland development
GO_0009611	Biological process	response to wounding
GO_0070848	Biological process	response to growth factor
GO_1904520	Biological process	regulation of myofibroblast cell apoptotic process
GO_0001714	Biological process	endodermal cell fate specification
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0035019	Biological process	somatic stem cell population maintenance
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565	Molecular function	sequence-specific DNA binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0035198	Molecular function	miRNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SOX2
Protein name	SRY (Sex determining region Y)-box 2 (Transcription factor SOX-2) Transcription factor SOX-2 Sex determining region Y-box 2
Synonyms	hCG_2021649
Description	FUNCTION: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency . Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity). .
Accessions	A0A0U3FYV6 A0A0B5HP19 A0A0B5HFE5 A0A0B5HFB3 A0A0B5HLA0 P48431 A0A0B5HSU3 ENST00000325404.3

SOX2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review