I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| respiratory goblet cell | 3 studies | 23% ± 7% | |
| epithelial cell | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| respiratory goblet cell | 3 studies | 23% ± 7% | |
| epithelial cell | 3 studies | 17% ± 1% |
Insufficient scRNA-seq data for expression of MESP1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 446.17 | 2622 / 2642 | 99% | 6.70 | 698 / 705 |
| prostate | 95% | 1121.68 | 233 / 245 | 99% | 86.75 | 499 / 502 |
| breast | 97% | 442.87 | 447 / 459 | 59% | 6.92 | 660 / 1118 |
| adrenal gland | 99% | 193.68 | 256 / 258 | 53% | 2.54 | 121 / 230 |
| kidney | 87% | 96.27 | 77 / 89 | 62% | 2.94 | 559 / 901 |
| intestine | 86% | 156.38 | 831 / 966 | 50% | 3.56 | 261 / 527 |
| thymus | 71% | 79.45 | 463 / 653 | 61% | 2.80 | 371 / 605 |
| liver | 56% | 50.21 | 126 / 226 | 61% | 2.96 | 246 / 406 |
| ovary | 20% | 14.81 | 36 / 180 | 87% | 9.38 | 372 / 430 |
| pancreas | 79% | 84.12 | 258 / 328 | 22% | 1.01 | 40 / 178 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.94 | 1 / 1 |
| muscle | 99% | 363.93 | 795 / 803 | 0% | 0 | 0 / 0 |
| adipose | 96% | 449.20 | 1154 / 1204 | 0% | 0 | 0 / 0 |
| stomach | 42% | 39.47 | 151 / 359 | 48% | 2.87 | 136 / 286 |
| uterus | 14% | 11.22 | 24 / 170 | 68% | 7.84 | 312 / 459 |
| heart | 82% | 115.11 | 704 / 861 | 0% | 0 | 0 / 0 |
| bladder | 29% | 23.57 | 6 / 21 | 53% | 6.39 | 266 / 504 |
| lung | 21% | 18.05 | 121 / 578 | 57% | 3.99 | 664 / 1155 |
| esophagus | 44% | 38.07 | 632 / 1445 | 27% | 1.41 | 50 / 183 |
| skin | 17% | 13.99 | 303 / 1809 | 53% | 2.26 | 252 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 40% | 2.20 | 18 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 28% | 0.92 | 8 / 29 |
| eye | 0% | 0 | 0 / 0 | 20% | 0.68 | 16 / 80 |
| blood vessel | 12% | 20.01 | 156 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 11% | 7.29 | 26 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 6% | 5.84 | 60 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0042662 | Biological process | negative regulation of mesodermal cell fate specification |
| GO_0003241 | Biological process | growth involved in heart morphogenesis |
| GO_0003259 | Biological process | cardioblast anterior-lateral migration |
| GO_0003211 | Biological process | cardiac ventricle formation |
| GO_0060975 | Biological process | cardioblast migration to the midline involved in heart field formation |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0003210 | Biological process | cardiac atrium formation |
| GO_0045446 | Biological process | endothelial cell differentiation |
| GO_0048368 | Biological process | lateral mesoderm development |
| GO_0055007 | Biological process | cardiac muscle cell differentiation |
| GO_0001947 | Biological process | heart looping |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0032525 | Biological process | somite rostral/caudal axis specification |
| GO_0060921 | Biological process | sinoatrial node cell differentiation |
| GO_0070368 | Biological process | positive regulation of hepatocyte differentiation |
| GO_0007369 | Biological process | gastrulation |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_0060947 | Biological process | cardiac vascular smooth muscle cell differentiation |
| GO_0003007 | Biological process | heart morphogenesis |
| GO_0023019 | Biological process | signal transduction involved in regulation of gene expression |
| GO_0008078 | Biological process | mesodermal cell migration |
| GO_0003129 | Biological process | heart induction |
| GO_0022008 | Biological process | neurogenesis |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0001707 | Biological process | mesoderm formation |
| GO_0042664 | Biological process | negative regulation of endodermal cell fate specification |
| GO_0060913 | Biological process | cardiac cell fate determination |
| GO_0051155 | Biological process | positive regulation of striated muscle cell differentiation |
| GO_0010467 | Biological process | gene expression |
| GO_0045747 | Biological process | positive regulation of Notch signaling pathway |
| GO_0003139 | Biological process | secondary heart field specification |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0003236 | Biological process | sinus venosus morphogenesis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0003143 | Biological process | embryonic heart tube morphogenesis |
| GO_0005634 | Cellular component | nucleus |
| GO_0000785 | Cellular component | chromatin |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0046983 | Molecular function | protein dimerization activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MESP1 |
| Protein name | Mesoderm posterior protein 1 (Class C basic helix-loop-helix protein 5) (bHLHc5) |
| Synonyms | BHLHC5 |
| Description | FUNCTION: Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity). . |
| Accessions | Q9BRJ9 ENST00000300057.5 |
