MCC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0010633Biological processnegative regulation of epithelial cell migration
GO_0016055Biological processWnt signaling pathway
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0045184Biological processestablishment of protein localization
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0030027Cellular componentlamellipodium
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0038023Molecular functionsignaling receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMCC
Protein nameMCC regulator of WNT signaling pathway
Colorectal mutant cancer protein (Protein MCC)
Synonyms
DescriptionFUNCTION: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation . Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity . .

AccessionsP23508
ENST00000408903.7 [P23508-2]
ENST00000514701.5
ENST00000302475.9 [P23508-1]
ENST00000515367.6
ENST00000624689.3
A0A096LPB3
D6REY2
A0A096LNU0