Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 24 studies | 35% ± 15% | |
astrocyte | 17 studies | 45% ± 21% | |
fibroblast | 12 studies | 28% ± 11% | |
pericyte | 10 studies | 27% ± 10% | |
basal cell | 8 studies | 38% ± 22% | |
adipocyte | 8 studies | 26% ± 7% | |
macrophage | 6 studies | 24% ± 14% | |
retinal cone cell | 6 studies | 44% ± 25% | |
GABAergic neuron | 6 studies | 45% ± 16% | |
retinal bipolar neuron | 5 studies | 49% ± 26% | |
interneuron | 5 studies | 54% ± 20% | |
cardiac muscle cell | 5 studies | 26% ± 5% | |
smooth muscle cell | 5 studies | 24% ± 8% | |
epithelial cell | 4 studies | 34% ± 16% | |
oligodendrocyte precursor cell | 4 studies | 21% ± 5% | |
retinal pigment epithelial cell | 4 studies | 38% ± 16% | |
capillary endothelial cell | 4 studies | 32% ± 7% | |
mesothelial cell | 4 studies | 29% ± 8% | |
hepatocyte | 4 studies | 56% ± 15% | |
GABAergic interneuron | 3 studies | 23% ± 3% | |
microglial cell | 3 studies | 52% ± 9% | |
endothelial cell of artery | 3 studies | 29% ± 7% | |
vein endothelial cell | 3 studies | 23% ± 4% | |
OFF-bipolar cell | 3 studies | 38% ± 13% | |
ON-bipolar cell | 3 studies | 69% ± 21% | |
retina horizontal cell | 3 studies | 35% ± 12% | |
rod bipolar cell | 3 studies | 56% ± 18% | |
endothelial cell of vascular tree | 3 studies | 34% ± 8% | |
glutamatergic neuron | 3 studies | 37% ± 9% | |
abnormal cell | 3 studies | 19% ± 4% | |
ependymal cell | 3 studies | 36% ± 25% | |
club cell | 3 studies | 23% ± 5% | |
myofibroblast cell | 3 studies | 24% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 97% | 1619.80 | 2573 / 2642 | 98% | 16.12 | 694 / 705 |
skin | 100% | 4874.10 | 1805 / 1809 | 93% | 24.39 | 441 / 472 |
breast | 100% | 3132.70 | 459 / 459 | 90% | 13.33 | 1006 / 1118 |
uterus | 100% | 4920.52 | 170 / 170 | 85% | 12.39 | 391 / 459 |
esophagus | 100% | 2546.92 | 1445 / 1445 | 84% | 18.75 | 153 / 183 |
prostate | 100% | 4102.98 | 245 / 245 | 80% | 7.71 | 402 / 502 |
thymus | 99% | 1531.26 | 648 / 653 | 80% | 6.69 | 485 / 605 |
kidney | 100% | 1520.83 | 89 / 89 | 75% | 7.58 | 676 / 901 |
lung | 100% | 2375.84 | 576 / 578 | 72% | 9.08 | 827 / 1155 |
bladder | 100% | 3934.29 | 21 / 21 | 66% | 9.02 | 331 / 504 |
adrenal gland | 81% | 632.83 | 208 / 258 | 83% | 8.89 | 191 / 230 |
ovary | 100% | 22038.03 | 180 / 180 | 55% | 3.81 | 238 / 430 |
liver | 100% | 2430.89 | 226 / 226 | 45% | 3.11 | 184 / 406 |
pancreas | 41% | 284.33 | 136 / 328 | 90% | 7.69 | 161 / 178 |
stomach | 91% | 1352.87 | 326 / 359 | 40% | 2.97 | 114 / 286 |
intestine | 92% | 1341.79 | 891 / 966 | 26% | 1.80 | 137 / 527 |
adipose | 100% | 3134.90 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 23.62 | 80 / 80 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.83 | 1 / 1 |
heart | 100% | 2221.48 | 857 / 861 | 0% | 0 | 0 / 0 |
spleen | 98% | 1179.60 | 237 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 17.32 | 43 / 45 |
blood vessel | 94% | 1208.77 | 1253 / 1335 | 0% | 0 | 0 / 0 |
muscle | 80% | 738.89 | 645 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 38% | 1.91 | 11 / 29 |
peripheral blood | 11% | 86.93 | 105 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0010633 | Biological process | negative regulation of epithelial cell migration |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0050680 | Biological process | negative regulation of epithelial cell proliferation |
GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
GO_0045184 | Biological process | establishment of protein localization |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0030027 | Cellular component | lamellipodium |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0038023 | Molecular function | signaling receptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | MCC |
Protein name | MCC regulator of WNT signaling pathway Colorectal mutant cancer protein (Protein MCC) |
Synonyms | |
Description | FUNCTION: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation . Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity . . |
Accessions | P23508 ENST00000408903.7 [P23508-2] ENST00000514701.5 ENST00000302475.9 [P23508-1] ENST00000515367.6 ENST00000624689.3 A0A096LPB3 D6REY2 A0A096LNU0 |