I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| microglial cell | 4 studies | 21% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| microglial cell | 4 studies | 21% ± 6% |
Insufficient scRNA-seq data for expression of WNT5A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 98% | 2203.09 | 1419 / 1445 | 97% | 48.57 | 178 / 183 |
| pancreas | 98% | 675.54 | 323 / 328 | 91% | 20.85 | 162 / 178 |
| lung | 98% | 986.81 | 565 / 578 | 90% | 35.60 | 1036 / 1155 |
| intestine | 99% | 730.44 | 961 / 966 | 85% | 13.35 | 447 / 527 |
| thymus | 99% | 863.67 | 646 / 653 | 85% | 14.56 | 512 / 605 |
| uterus | 98% | 3003.60 | 167 / 170 | 82% | 20.62 | 378 / 459 |
| prostate | 99% | 1442.38 | 242 / 245 | 80% | 18.11 | 403 / 502 |
| stomach | 90% | 464.79 | 324 / 359 | 86% | 14.83 | 246 / 286 |
| ovary | 100% | 2456.27 | 180 / 180 | 73% | 9.65 | 316 / 430 |
| bladder | 86% | 3607.81 | 18 / 21 | 86% | 36.63 | 435 / 504 |
| breast | 81% | 632.35 | 374 / 459 | 76% | 15.68 | 848 / 1118 |
| brain | 67% | 259.03 | 1777 / 2642 | 87% | 14.43 | 614 / 705 |
| skin | 98% | 6882.04 | 1765 / 1809 | 21% | 4.07 | 98 / 472 |
| spleen | 98% | 762.16 | 236 / 241 | 0% | 0 | 0 / 0 |
| kidney | 55% | 397.61 | 49 / 89 | 41% | 7.84 | 372 / 901 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 28.51 | 42 / 45 |
| liver | 54% | 222.62 | 122 / 226 | 30% | 2.80 | 122 / 406 |
| adrenal gland | 53% | 158.05 | 137 / 258 | 15% | 1.87 | 34 / 230 |
| heart | 58% | 236.12 | 497 / 861 | 0% | 0 | 0 / 0 |
| adipose | 55% | 353.27 | 659 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 36% | 112.01 | 293 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 21% | 96.07 | 283 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 1.79 | 3 / 29 |
| peripheral blood | 4% | 22.82 | 35 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007254 | Biological process | JNK cascade |
| GO_0032722 | Biological process | positive regulation of chemokine production |
| GO_0060599 | Biological process | lateral sprouting involved in mammary gland duct morphogenesis |
| GO_0045198 | Biological process | establishment of epithelial cell apical/basal polarity |
| GO_0010742 | Biological process | macrophage derived foam cell differentiation |
| GO_0071560 | Biological process | cellular response to transforming growth factor beta stimulus |
| GO_0030324 | Biological process | lung development |
| GO_0048146 | Biological process | positive regulation of fibroblast proliferation |
| GO_0006954 | Biological process | inflammatory response |
| GO_0060775 | Biological process | planar cell polarity pathway involved in gastrula mediolateral intercalation |
| GO_0010976 | Biological process | positive regulation of neuron projection development |
| GO_0001947 | Biological process | heart looping |
| GO_0090009 | Biological process | primitive streak formation |
| GO_0042733 | Biological process | embryonic digit morphogenesis |
| GO_0003138 | Biological process | primary heart field specification |
| GO_0030514 | Biological process | negative regulation of BMP signaling pathway |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_0071425 | Biological process | hematopoietic stem cell proliferation |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
| GO_1904862 | Biological process | inhibitory synapse assembly |
| GO_0002053 | Biological process | positive regulation of mesenchymal cell proliferation |
| GO_0060068 | Biological process | vagina development |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0036342 | Biological process | post-anal tail morphogenesis |
| GO_0003323 | Biological process | type B pancreatic cell development |
| GO_0099054 | Biological process | presynapse assembly |
| GO_1900020 | Biological process | positive regulation of protein kinase C activity |
| GO_2001235 | Biological process | positive regulation of apoptotic signaling pathway |
| GO_0045778 | Biological process | positive regulation of ossification |
| GO_0060686 | Biological process | negative regulation of prostatic bud formation |
| GO_0001736 | Biological process | establishment of planar polarity |
| GO_0071300 | Biological process | cellular response to retinoic acid |
| GO_0003408 | Biological process | optic cup formation involved in camera-type eye development |
| GO_0060744 | Biological process | mammary gland branching involved in thelarche |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0060750 | Biological process | epithelial cell proliferation involved in mammary gland duct elongation |
| GO_0070245 | Biological process | positive regulation of thymocyte apoptotic process |
| GO_0007494 | Biological process | midgut development |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0045599 | Biological process | negative regulation of fat cell differentiation |
| GO_0001822 | Biological process | kidney development |
| GO_1904934 | Biological process | negative regulation of cell proliferation in midbrain |
| GO_1904861 | Biological process | excitatory synapse assembly |
| GO_0048570 | Biological process | notochord morphogenesis |
| GO_0050727 | Biological process | regulation of inflammatory response |
| GO_0060067 | Biological process | cervix development |
| GO_0070242 | Biological process | thymocyte apoptotic process |
| GO_0043032 | Biological process | positive regulation of macrophage activation |
| GO_0071277 | Biological process | cellular response to calcium ion |
| GO_0042060 | Biological process | wound healing |
| GO_0021891 | Biological process | olfactory bulb interneuron development |
| GO_0045732 | Biological process | positive regulation of protein catabolic process |
| GO_0030182 | Biological process | neuron differentiation |
| GO_0050807 | Biological process | regulation of synapse organization |
| GO_0045165 | Biological process | cell fate commitment |
| GO_0048706 | Biological process | embryonic skeletal system development |
| GO_0051964 | Biological process | negative regulation of synapse assembly |
| GO_0060324 | Biological process | face development |
| GO_0010463 | Biological process | mesenchymal cell proliferation |
| GO_0032757 | Biological process | positive regulation of interleukin-8 production |
| GO_0071222 | Biological process | cellular response to lipopolysaccharide |
| GO_0007442 | Biological process | hindgut morphogenesis |
| GO_0051885 | Biological process | positive regulation of timing of anagen |
| GO_0050729 | Biological process | positive regulation of inflammatory response |
| GO_0035567 | Biological process | non-canonical Wnt signaling pathway |
| GO_0043122 | Biological process | regulation of canonical NF-kappaB signal transduction |
| GO_0061354 | Biological process | planar cell polarity pathway involved in pericardium morphogenesis |
| GO_2000052 | Biological process | positive regulation of non-canonical Wnt signaling pathway |
| GO_0036518 | Biological process | chemorepulsion of dopaminergic neuron axon |
| GO_0051216 | Biological process | cartilage development |
| GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
| GO_0040037 | Biological process | negative regulation of fibroblast growth factor receptor signaling pathway |
| GO_0032755 | Biological process | positive regulation of interleukin-6 production |
| GO_0008543 | Biological process | fibroblast growth factor receptor signaling pathway |
| GO_0048843 | Biological process | negative regulation of axon extension involved in axon guidance |
| GO_0030216 | Biological process | keratinocyte differentiation |
| GO_0099068 | Biological process | postsynapse assembly |
| GO_0032148 | Biological process | activation of protein kinase B activity |
| GO_0060340 | Biological process | positive regulation of type I interferon-mediated signaling pathway |
| GO_0048341 | Biological process | paraxial mesoderm formation |
| GO_0003402 | Biological process | planar cell polarity pathway involved in axis elongation |
| GO_0072201 | Biological process | negative regulation of mesenchymal cell proliferation |
| GO_0010631 | Biological process | epithelial cell migration |
| GO_0007223 | Biological process | Wnt signaling pathway, calcium modulating pathway |
| GO_0033138 | Biological process | positive regulation of peptidyl-serine phosphorylation |
| GO_0010820 | Biological process | positive regulation of T cell chemotaxis |
| GO_0045807 | Biological process | positive regulation of endocytosis |
| GO_0048806 | Biological process | genitalia development |
| GO_0048022 | Biological process | negative regulation of melanin biosynthetic process |
| GO_0032731 | Biological process | positive regulation of interleukin-1 beta production |
| GO_0003283 | Biological process | atrial septum development |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0060029 | Biological process | convergent extension involved in organogenesis |
| GO_0060065 | Biological process | uterus development |
| GO_0001756 | Biological process | somitogenesis |
| GO_0061348 | Biological process | planar cell polarity pathway involved in ventricular septum morphogenesis |
| GO_0090037 | Biological process | positive regulation of protein kinase C signaling |
| GO_0060907 | Biological process | positive regulation of macrophage cytokine production |
| GO_2000049 | Biological process | positive regulation of cell-cell adhesion mediated by cadherin |
| GO_0008584 | Biological process | male gonad development |
| GO_0060638 | Biological process | mesenchymal-epithelial cell signaling |
| GO_0036517 | Biological process | chemoattraction of serotonergic neuron axon |
| GO_0016055 | Biological process | Wnt signaling pathway |
| GO_0061347 | Biological process | planar cell polarity pathway involved in outflow tract morphogenesis |
| GO_0097325 | Biological process | melanocyte proliferation |
| GO_0061350 | Biological process | planar cell polarity pathway involved in cardiac muscle tissue morphogenesis |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0061036 | Biological process | positive regulation of cartilage development |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0071346 | Biological process | cellular response to type II interferon |
| GO_0043507 | Biological process | positive regulation of JUN kinase activity |
| GO_1902474 | Biological process | positive regulation of protein localization to synapse |
| GO_0060762 | Biological process | regulation of branching involved in mammary gland duct morphogenesis |
| GO_0001837 | Biological process | epithelial to mesenchymal transition |
| GO_0099566 | Biological process | regulation of postsynaptic cytosolic calcium ion concentration |
| GO_1904948 | Biological process | midbrain dopaminergic neuron differentiation |
| GO_0060028 | Biological process | convergent extension involved in axis elongation |
| GO_1902035 | Biological process | positive regulation of hematopoietic stem cell proliferation |
| GO_0002720 | Biological process | positive regulation of cytokine production involved in immune response |
| GO_0046330 | Biological process | positive regulation of JNK cascade |
| GO_0010595 | Biological process | positive regulation of endothelial cell migration |
| GO_0008595 | Biological process | anterior/posterior axis specification, embryo |
| GO_0062009 | Biological process | secondary palate development |
| GO_0060760 | Biological process | positive regulation of response to cytokine stimulus |
| GO_0048846 | Biological process | axon extension involved in axon guidance |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0090103 | Biological process | cochlea morphogenesis |
| GO_0140013 | Biological process | meiotic nuclear division |
| GO_0050680 | Biological process | negative regulation of epithelial cell proliferation |
| GO_0060070 | Biological process | canonical Wnt signaling pathway |
| GO_0060157 | Biological process | urinary bladder development |
| GO_0061349 | Biological process | planar cell polarity pathway involved in cardiac right atrium morphogenesis |
| GO_0090179 | Biological process | planar cell polarity pathway involved in neural tube closure |
| GO_0150012 | Biological process | positive regulation of neuron projection arborization |
| GO_0001938 | Biological process | positive regulation of endothelial cell proliferation |
| GO_0045836 | Biological process | positive regulation of meiotic nuclear division |
| GO_0060809 | Biological process | mesodermal to mesenchymal transition involved in gastrulation |
| GO_0002088 | Biological process | lens development in camera-type eye |
| GO_0060071 | Biological process | Wnt signaling pathway, planar cell polarity pathway |
| GO_0008104 | Biological process | protein localization |
| GO_0032729 | Biological process | positive regulation of type II interferon production |
| GO_0048850 | Biological process | hypophysis morphogenesis |
| GO_0099170 | Biological process | postsynaptic modulation of chemical synaptic transmission |
| GO_0010800 | Biological process | positive regulation of peptidyl-threonine phosphorylation |
| GO_0003139 | Biological process | secondary heart field specification |
| GO_0007411 | Biological process | axon guidance |
| GO_0099175 | Biological process | regulation of postsynapse organization |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0030669 | Cellular component | clathrin-coated endocytic vesicle membrane |
| GO_0098794 | Cellular component | postsynapse |
| GO_0009986 | Cellular component | cell surface |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0005576 | Cellular component | extracellular region |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0030666 | Cellular component | endocytic vesicle membrane |
| GO_0005796 | Cellular component | Golgi lumen |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0048018 | Molecular function | receptor ligand activity |
| GO_0005115 | Molecular function | receptor tyrosine kinase-like orphan receptor binding |
| GO_0005125 | Molecular function | cytokine activity |
| GO_0019904 | Molecular function | protein domain specific binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005543 | Molecular function | phospholipid binding |
| GO_0005109 | Molecular function | frizzled binding |
| GO_1902379 | Molecular function | chemoattractant activity involved in axon guidance |
| Gene name | WNT5A |
| Protein name | Wingless-type MMTV integration site family member 5A variant 2 Protein Wnt-5a Protein Wnt |
| Synonyms | |
| Description | FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor . Mediates motility of melanoma cells . Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity). . FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. . FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. . |
| Accessions | ENST00000264634.9 [P41221-1] ENST00000474267.5 [P41221-1] Q6DK41 ENST00000482079.1 ENST00000497027.5 [P41221-2] P41221 C9J8I8 A0FKN4 |
