AXIN2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of AXIN2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AXIN2 at tissue level.

III. Associated gene sets

GO_0033687Biological processosteoblast proliferation
GO_0003413Biological processchondrocyte differentiation involved in endochondral bone morphogenesis
GO_0042476Biological processodontogenesis
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0070602Biological processregulation of centromeric sister chromatid cohesion
GO_0033689Biological processnegative regulation of osteoblast proliferation
GO_0003183Biological processmitral valve morphogenesis
GO_0001649Biological processosteoblast differentiation
GO_0032423Biological processregulation of mismatch repair
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0001957Biological processintramembranous ossification
GO_0003180Biological processaortic valve morphogenesis
GO_0048255Biological processmRNA stabilization
GO_0072089Biological processstem cell proliferation
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0009950Biological processdorsal/ventral axis specification
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0048468Biological processcell development
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0030282Biological processbone mineralization
GO_1903053Biological processregulation of extracellular matrix organization
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0001756Biological processsomitogenesis
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0008104Biological processprotein localization
GO_0003139Biological processsecondary heart field specification
GO_0043570Biological processmaintenance of DNA repeat elements
GO_0061181Biological processregulation of chondrocyte development
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005886Cellular componentplasma membrane
GO_0005813Cellular componentcentrosome
GO_0030877Cellular componentbeta-catenin destruction complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0019901Molecular functionprotein kinase binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008013Molecular functionbeta-catenin binding
GO_0070411Molecular functionI-SMAD binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAXIN2
Protein nameAxin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)
Axin 2
AXIN2 protein
Synonyms
DescriptionFUNCTION: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. .

AccessionsENST00000580513.1
Q9BRF5
F5GX43
ENST00000544103.2
B7ZKL5
E7ES00
ENST00000375702.5
A0A1B0GX50
ENST00000307078.10
Q9Y2T1
ENST00000618960.4
J3QRK4
J3QQJ3
ENST00000585045.1
ENST00000577278.1