Insufficient scRNA-seq data for expression of AXIN2 at single-cell level.
Insufficient scRNA-seq data for expression of AXIN2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 1065.32 | 2610 / 2642 | 99% | 12.48 | 695 / 705 |
prostate | 100% | 2694.96 | 245 / 245 | 97% | 13.68 | 485 / 502 |
ovary | 100% | 2799.92 | 180 / 180 | 97% | 14.57 | 415 / 430 |
intestine | 100% | 1700.62 | 965 / 966 | 94% | 76.59 | 497 / 527 |
stomach | 99% | 1313.47 | 355 / 359 | 90% | 64.38 | 257 / 286 |
thymus | 100% | 2574.22 | 651 / 653 | 86% | 9.67 | 520 / 605 |
lung | 100% | 3373.39 | 577 / 578 | 79% | 9.70 | 910 / 1155 |
breast | 97% | 1076.41 | 443 / 459 | 75% | 5.79 | 836 / 1118 |
pancreas | 71% | 402.92 | 232 / 328 | 93% | 10.21 | 166 / 178 |
esophagus | 98% | 1952.10 | 1422 / 1445 | 62% | 12.83 | 113 / 183 |
bladder | 100% | 2120.52 | 21 / 21 | 60% | 27.96 | 302 / 504 |
adrenal gland | 100% | 2058.23 | 257 / 258 | 51% | 4.43 | 118 / 230 |
uterus | 100% | 4553.85 | 170 / 170 | 50% | 8.51 | 230 / 459 |
skin | 94% | 1850.64 | 1705 / 1809 | 40% | 3.84 | 190 / 472 |
spleen | 100% | 1475.84 | 241 / 241 | 0% | 0 | 0 / 0 |
muscle | 98% | 1555.81 | 785 / 803 | 0% | 0 | 0 / 0 |
adipose | 98% | 1230.53 | 1174 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 96% | 1112.46 | 1282 / 1335 | 0% | 0 | 0 / 0 |
heart | 90% | 965.64 | 777 / 861 | 0% | 0 | 0 / 0 |
kidney | 57% | 436.83 | 51 / 89 | 23% | 1.55 | 208 / 901 |
liver | 38% | 156.97 | 87 / 226 | 30% | 5.72 | 120 / 406 |
tonsil | 0% | 0 | 0 / 0 | 31% | 2.07 | 14 / 45 |
eye | 0% | 0 | 0 / 0 | 29% | 1.46 | 23 / 80 |
peripheral blood | 11% | 49.48 | 98 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 7% | 0.35 | 2 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0033687 | Biological process | osteoblast proliferation |
GO_0003413 | Biological process | chondrocyte differentiation involved in endochondral bone morphogenesis |
GO_0042476 | Biological process | odontogenesis |
GO_0071549 | Biological process | cellular response to dexamethasone stimulus |
GO_0070602 | Biological process | regulation of centromeric sister chromatid cohesion |
GO_0033689 | Biological process | negative regulation of osteoblast proliferation |
GO_0003183 | Biological process | mitral valve morphogenesis |
GO_0001649 | Biological process | osteoblast differentiation |
GO_0032423 | Biological process | regulation of mismatch repair |
GO_0032436 | Biological process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
GO_0001957 | Biological process | intramembranous ossification |
GO_0003180 | Biological process | aortic valve morphogenesis |
GO_0048255 | Biological process | mRNA stabilization |
GO_0072089 | Biological process | stem cell proliferation |
GO_0001934 | Biological process | positive regulation of protein phosphorylation |
GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
GO_0009950 | Biological process | dorsal/ventral axis specification |
GO_0045860 | Biological process | positive regulation of protein kinase activity |
GO_0060070 | Biological process | canonical Wnt signaling pathway |
GO_0048468 | Biological process | cell development |
GO_0045600 | Biological process | positive regulation of fat cell differentiation |
GO_0030282 | Biological process | bone mineralization |
GO_1903053 | Biological process | regulation of extracellular matrix organization |
GO_0045668 | Biological process | negative regulation of osteoblast differentiation |
GO_0001756 | Biological process | somitogenesis |
GO_0010718 | Biological process | positive regulation of epithelial to mesenchymal transition |
GO_0008104 | Biological process | protein localization |
GO_0003139 | Biological process | secondary heart field specification |
GO_0043570 | Biological process | maintenance of DNA repeat elements |
GO_0061181 | Biological process | regulation of chondrocyte development |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0005886 | Cellular component | plasma membrane |
GO_0005813 | Cellular component | centrosome |
GO_0030877 | Cellular component | beta-catenin destruction complex |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0019899 | Molecular function | enzyme binding |
GO_0060090 | Molecular function | molecular adaptor activity |
GO_0019901 | Molecular function | protein kinase binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0008013 | Molecular function | beta-catenin binding |
GO_0070411 | Molecular function | I-SMAD binding |
GO_0005515 | Molecular function | protein binding |
Gene name | AXIN2 |
Protein name | Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin) Axin 2 AXIN2 protein |
Synonyms | |
Description | FUNCTION: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. . |
Accessions | ENST00000580513.1 Q9BRF5 F5GX43 ENST00000544103.2 B7ZKL5 E7ES00 ENST00000375702.5 A0A1B0GX50 ENST00000307078.10 Q9Y2T1 ENST00000618960.4 J3QRK4 J3QQJ3 ENST00000585045.1 ENST00000577278.1 |