Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 12 studies | 26% ± 12% | |
macrophage | 8 studies | 22% ± 5% | |
glutamatergic neuron | 7 studies | 40% ± 24% | |
interneuron | 6 studies | 35% ± 22% | |
oligodendrocyte precursor cell | 6 studies | 27% ± 12% | |
GABAergic neuron | 6 studies | 38% ± 21% | |
astrocyte | 6 studies | 30% ± 11% | |
oligodendrocyte | 6 studies | 26% ± 8% | |
natural killer cell | 5 studies | 19% ± 3% | |
neuron | 5 studies | 27% ± 10% | |
epithelial cell | 5 studies | 35% ± 12% | |
T cell | 5 studies | 19% ± 8% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 18% ± 2% | |
CD16-positive, CD56-dim natural killer cell, human | 4 studies | 19% ± 2% | |
CD8-positive, alpha-beta T cell | 4 studies | 21% ± 2% | |
microglial cell | 4 studies | 28% ± 5% | |
myeloid cell | 4 studies | 23% ± 4% | |
ciliated cell | 4 studies | 25% ± 4% | |
lymphocyte | 4 studies | 21% ± 4% | |
basal cell | 4 studies | 24% ± 9% | |
endothelial cell of lymphatic vessel | 4 studies | 18% ± 3% | |
B cell | 3 studies | 23% ± 4% | |
classical monocyte | 3 studies | 24% ± 6% | |
hematopoietic precursor cell | 3 studies | 22% ± 6% | |
mature NK T cell | 3 studies | 17% ± 1% | |
granule cell | 3 studies | 19% ± 3% | |
dendritic cell | 3 studies | 27% ± 12% | |
fibroblast | 3 studies | 18% ± 2% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 16% ± 1% | |
gamma-delta T cell | 3 studies | 21% ± 7% | |
goblet cell | 3 studies | 26% ± 10% | |
transit amplifying cell | 3 studies | 25% ± 11% | |
adipocyte | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 4448.82 | 1445 / 1445 | 100% | 19.58 | 183 / 183 |
breast | 100% | 4506.26 | 459 / 459 | 100% | 20.17 | 1116 / 1118 |
stomach | 100% | 3585.88 | 359 / 359 | 100% | 12.26 | 285 / 286 |
bladder | 100% | 4565.86 | 21 / 21 | 100% | 12.18 | 502 / 504 |
prostate | 100% | 4666.15 | 245 / 245 | 100% | 15.01 | 500 / 502 |
ovary | 100% | 4784.73 | 180 / 180 | 100% | 14.50 | 428 / 430 |
brain | 100% | 3986.20 | 2633 / 2642 | 100% | 17.76 | 703 / 705 |
intestine | 100% | 4686.21 | 966 / 966 | 99% | 11.12 | 523 / 527 |
uterus | 100% | 5276.84 | 170 / 170 | 99% | 13.92 | 455 / 459 |
lung | 100% | 4322.56 | 578 / 578 | 99% | 14.77 | 1144 / 1155 |
skin | 100% | 6740.78 | 1809 / 1809 | 99% | 15.83 | 466 / 472 |
thymus | 100% | 5220.94 | 653 / 653 | 99% | 13.17 | 597 / 605 |
pancreas | 99% | 2281.46 | 326 / 328 | 99% | 11.83 | 176 / 178 |
kidney | 100% | 3143.92 | 89 / 89 | 96% | 9.87 | 862 / 901 |
adrenal gland | 100% | 3858.56 | 258 / 258 | 93% | 8.85 | 214 / 230 |
liver | 100% | 1674.08 | 225 / 226 | 84% | 5.62 | 341 / 406 |
adipose | 100% | 4103.89 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4148.84 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 13.74 | 29 / 29 |
muscle | 100% | 2959.83 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 5395.99 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 15.10 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.62 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 98% | 13.43 | 78 / 80 |
heart | 97% | 2272.48 | 836 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 95% | 3685.95 | 887 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032508 | Biological process | DNA duplex unwinding |
GO_0006397 | Biological process | mRNA processing |
GO_2000270 | Biological process | negative regulation of fibroblast apoptotic process |
GO_0001701 | Biological process | in utero embryonic development |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
GO_0006338 | Biological process | chromatin remodeling |
GO_0045945 | Biological process | positive regulation of transcription by RNA polymerase III |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0048565 | Biological process | digestive tract development |
GO_0007420 | Biological process | brain development |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0060134 | Biological process | prepulse inhibition |
GO_0035176 | Biological process | social behavior |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0071339 | Cellular component | MLL1 complex |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0035064 | Molecular function | methylated histone binding |
GO_0003677 | Molecular function | DNA binding |
GO_0042393 | Molecular function | histone binding |
GO_0003682 | Molecular function | chromatin binding |
GO_0008013 | Molecular function | beta-catenin binding |
GO_0003678 | Molecular function | DNA helicase activity |
GO_0002039 | Molecular function | p53 binding |
GO_0005524 | Molecular function | ATP binding |
GO_0140658 | Molecular function | ATP-dependent chromatin remodeler activity |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | CHD8 |
Protein name | Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1) Alternative protein CHD8 Chromodomain helicase DNA binding protein 8 DNA helicase (EC 3.6.4.12) |
Synonyms | KIAA1564 HELSNF1 |
Description | FUNCTION: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. . |
Accessions | ENST00000553870.2 ENST00000555962.6 L8E914 ENST00000557364.6 [Q9HCK8-1] A0A2R8Y840 H0YJG4 ENST00000646340.1 ENST00000646647.2 [Q9HCK8-1] H0YJA4 ENST00000553622.5 ENST00000642518.1 ENST00000645929.1 [Q9HCK8-2] Q9HCK8 A0A2R8Y4P3 ENST00000645140.1 ENST00000430710.8 [Q9HCK8-2] ENST00000643469.1 [Q9HCK8-1] A0A2R8Y808 ENST00000555935.2 G3V303 A0A2R8YFT4 ENST00000646063.1 A0A2R8YFI9 |