CHD8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0006397Biological processmRNA processing
GO_2000270Biological processnegative regulation of fibroblast apoptotic process
GO_0001701Biological processin utero embryonic development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0006338Biological processchromatin remodeling
GO_0045945Biological processpositive regulation of transcription by RNA polymerase III
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0048565Biological processdigestive tract development
GO_0007420Biological processbrain development
GO_0016055Biological processWnt signaling pathway
GO_0060134Biological processprepulse inhibition
GO_0035176Biological processsocial behavior
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071339Cellular componentMLL1 complex
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0003677Molecular functionDNA binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0008013Molecular functionbeta-catenin binding
GO_0003678Molecular functionDNA helicase activity
GO_0002039Molecular functionp53 binding
GO_0005524Molecular functionATP binding
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameCHD8
Protein nameChromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Helicase with SNF2 domain 1)
Alternative protein CHD8
Chromodomain helicase DNA binding protein 8
DNA helicase (EC 3.6.4.12)
SynonymsKIAA1564
HELSNF1
DescriptionFUNCTION: DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co-transcriptional RNA processing likely via interaction with HNRNPL. .

AccessionsENST00000553870.2
ENST00000555962.6
L8E914
ENST00000557364.6 [Q9HCK8-1]
A0A2R8Y840
H0YJG4
ENST00000646340.1
ENST00000646647.2 [Q9HCK8-1]
H0YJA4
ENST00000553622.5
ENST00000642518.1
ENST00000645929.1 [Q9HCK8-2]
Q9HCK8
A0A2R8Y4P3
ENST00000645140.1
ENST00000430710.8 [Q9HCK8-2]
ENST00000643469.1 [Q9HCK8-1]
A0A2R8Y808
ENST00000555935.2
G3V303
A0A2R8YFT4
ENST00000646063.1
A0A2R8YFI9