G3BP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0007265Biological processRas protein signal transduction
GO_0034063Biological processstress granule assembly
GO_0045087Biological processinnate immune response
GO_0051607Biological processdefense response to virus
GO_0062029Biological processpositive regulation of stress granule assembly
GO_0032481Biological processpositive regulation of type I interferon production
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0043204Cellular componentperikaryon
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0004519Molecular functionendonuclease activity
GO_0003724Molecular functionRNA helicase activity
GO_0043024Molecular functionribosomal small subunit binding
GO_0033677Molecular functionDNA/RNA helicase activity
GO_0003729Molecular functionmRNA binding
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0003678Molecular functionDNA helicase activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameG3BP1
Protein nameGTPase activating protein (SH3 domain) binding protein 1
G3BP stress granule assembly factor 1 (Ras GTPase-activating protein-binding protein 1)
G3BP stress granule assembly factor 1
Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1)
SynonymsG3BP
DescriptionFUNCTION: Protein involved in various processes, such as stress granule formation and innate immunity . Plays an essential role in stress granule formation . Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress . Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations . Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency . Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA . Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends . Plays an essential role in innate immunity by promoting CGAS and RIGI activity . Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS . Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles . Enhances also RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA . May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR . .

AccessionsQ32P45
ENST00000678825.1
ENST00000522761.6 [Q13283-1]
ENST00000676827.1 [Q13283-1]
A0A7P0P2U7
A0A7I2YQN9
ENST00000677608.1
ENST00000677381.1 [Q13283-2]
A0A7I2V2S5
ENST00000678854.1
ENST00000677687.1
ENST00000677493.1
A0A7I2YQM1
A0A7I2V565
ENST00000678500.1
A0A7I2YQP3
A0A7I2V326
ENST00000678372.1
A0A7I2V651
E5RH42
ENST00000676978.1 [Q13283-1]
A0A7I2YQR4
ENST00000677408.1
ENST00000678070.1 [Q13283-1]
ENST00000677211.1
ENST00000676590.1
A0A7I2V274
ENST00000676899.1
A0A7I2V3C4
ENST00000356245.8 [Q13283-1]
ENST00000676507.1
A0A7I2V4D8
A0A7I2V496
ENST00000679289.1
A0A7I2YQQ8
E5RIF8
A0A7I2V5M7
ENST00000677369.1
A0A7I2V2V1
ENST00000523519.5
A0A7I2V533
A0A7I2V548
ENST00000678101.1 [Q13283-1]
A0A7I2V2X7
Q13283
E5RI46
ENST00000678976.1
ENST00000678194.1
ENST00000678657.1
ENST00000676813.1
ENST00000678612.1
ENST00000520006.2
ENST00000517947.5
A0A7I2V3V2
ENST00000676734.1
ENST00000677105.1
A0A7I2V3Y4
ENST00000677146.1
ENST00000677854.1
ENST00000678910.1
ENST00000522666.1
ENST00000522367.6 [Q13283-2]
ENST00000522761
ENST00000678925.1 [Q13283-1]
ENST00000520578.6
ENST00000677923.1
A0A7I2YQB1
ENST00000678646.1
ENST00000676644.1
ENST00000677658.1
ENST00000678726.1
ENST00000520177.6
ENST00000677323.1 [Q13283-1]
ENST00000394123.7 [Q13283-1]
ENST00000678295.1
A0A7I2V5H1
ENST00000676878.1
A0A7I2YQU8
ENST00000627077.2
ENST00000677284.1
A0A7I2V494
ENST00000679004.1
A0A7I2YQC2
A0A7I2YQH0
ENST00000678964.1
ENST00000677433.1
E5RH00
E5RJU8
A0A7I2V4Y8
ENST00000676715.1
A0A7I2YQF2
ENST00000679135.1
ENST00000678564.1