SNAI2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0007605Biological processsensory perception of sound
GO_1902034Biological processnegative regulation of hematopoietic stem cell proliferation
GO_0001837Biological processepithelial to mesenchymal transition
GO_0003198Biological processepithelial to mesenchymal transition involved in endocardial cushion formation
GO_0007219Biological processNotch signaling pathway
GO_0033028Biological processmyeloid cell apoptotic process
GO_0045667Biological processregulation of osteoblast differentiation
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0006933Biological processnegative regulation of cell adhesion involved in substrate-bound cell migration
GO_0001649Biological processosteoblast differentiation
GO_0003180Biological processaortic valve morphogenesis
GO_2000811Biological processnegative regulation of anoikis
GO_0060693Biological processregulation of branching involved in salivary gland morphogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0033629Biological processnegative regulation of cell adhesion mediated by integrin
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0071425Biological processhematopoietic stem cell proliferation
GO_0033033Biological processnegative regulation of myeloid cell apoptotic process
GO_0014032Biological processneural crest cell development
GO_0003273Biological processcell migration involved in endocardial cushion formation
GO_0060536Biological processcartilage morphogenesis
GO_0010839Biological processnegative regulation of keratinocyte proliferation
GO_0032331Biological processnegative regulation of chondrocyte differentiation
GO_0060021Biological processroof of mouth development
GO_0030335Biological processpositive regulation of cell migration
GO_0070563Biological processnegative regulation of vitamin D receptor signaling pathway
GO_0043542Biological processendothelial cell migration
GO_2000810Biological processregulation of bicellular tight junction assembly
GO_0043473Biological processpigmentation
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_1902230Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO_0006355Biological processregulation of DNA-templated transcription
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0071479Biological processcellular response to ionizing radiation
GO_0060429Biological processepithelium development
GO_0010957Biological processnegative regulation of vitamin D biosynthetic process
GO_0043518Biological processnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO_0035921Biological processdesmosome disassembly
GO_0050872Biological processwhite fat cell differentiation
GO_0032642Biological processregulation of chemokine production
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0046872Molecular functionmetal ion binding
GO_0070888Molecular functionE-box binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSNAI2
Protein nameZinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2)
Snail family transcriptional repressor 2
SynonymsSLUG
SLUGH
DescriptionFUNCTION: Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. .

AccessionsENST00000020945.4
A0A1X7SC17
ENST00000396822.6
O43623