DKK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032348Biological processnegative regulation of aldosterone biosynthetic process
GO_0017015Biological processregulation of transforming growth factor beta receptor signaling pathway
GO_0016055Biological processWnt signaling pathway
GO_2000065Biological processnegative regulation of cortisol biosynthetic process
GO_0030325Biological processadrenal gland development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_1902613Biological processnegative regulation of anti-Mullerian hormone signaling pathway
GO_0009653Biological processanatomical structure morphogenesis
GO_0005615Cellular componentextracellular space
GO_0048019Molecular functionreceptor antagonist activity
GO_0039706Molecular functionco-receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDKK3
Protein namePutative tumor suppressor Dkk-3/REIC
Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (hDkk-3)
Dickkopf WNT signaling pathway inhibitor 3
SynonymsREIC
UNQ258/PRO295
DescriptionFUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). .

AccessionsENST00000326932.8
E9PKW6
Q6PQ81
ENST00000396505.7
ENST00000683431.1
Q9UBP4
ENST00000529338.1
ENST00000534511.5
ENST00000533813.5
F6SYF8
E9PKK9
ENST00000525493.5
E9PHY3