GPC3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	25 studies	52% ± 27%	Explore
connective tissue cell	11 studies	51% ± 29%	Explore
myofibroblast cell	6 studies	29% ± 12%	Explore
ciliated cell	6 studies	27% ± 8%	Explore
progenitor cell	5 studies	51% ± 27%	Explore
pericyte	5 studies	30% ± 15%	Explore
epithelial cell	4 studies	57% ± 18%	Explore
mesothelial cell	4 studies	68% ± 10%	Explore
smooth muscle cell	4 studies	34% ± 4%	Explore
kidney loop of Henle epithelial cell	3 studies	22% ± 5%	Explore
endothelial cell	3 studies	28% ± 12%	Explore
basal cell	3 studies	32% ± 9%	Explore
Mueller cell	3 studies	20% ± 1%	Explore
chondrocyte	3 studies	46% ± 18%	Explore
myoepithelial cell	3 studies	35% ± 26%	Explore
adipocyte	3 studies	34% ± 21%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
intestine	4 studies	30% ± 8%	Explore
lung	3 studies	38% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	13119.26	577 / 578	70%	98.56	807 / 1155
breast	100%	7079.64	459 / 459	56%	33.89	627 / 1118
kidney	92%	3268.79	82 / 89	28%	12.92	256 / 901
bladder	86%	1602.38	18 / 21	30%	23.39	150 / 504
ovary	69%	1526.21	124 / 180	41%	30.94	178 / 430
thymus	93%	2612.70	606 / 653	12%	2.82	73 / 605
adipose	100%	8879.17	1204 / 1204	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	13.62	1 / 1
stomach	63%	992.31	227 / 359	37%	29.61	105 / 286
adrenal gland	65%	1063.86	167 / 258	32%	24.86	74 / 230
pancreas	28%	335.53	93 / 328	68%	115.14	121 / 178
uterus	42%	612.85	71 / 170	47%	59.15	214 / 459
liver	4%	44.60	9 / 226	83%	682.83	336 / 406
skin	58%	1175.84	1046 / 1809	28%	24.21	130 / 472
prostate	38%	534.35	94 / 245	39%	7.15	196 / 502
esophagus	28%	500.43	407 / 1445	46%	66.47	85 / 183
intestine	31%	452.61	303 / 966	27%	12.80	140 / 527
blood vessel	58%	1308.26	769 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	49%	41.62	22 / 45
heart	48%	1001.60	415 / 861	0%	0	0 / 0
spleen	15%	239.96	37 / 241	0%	0	0 / 0
brain	1%	15.30	29 / 2642	7%	4.94	52 / 705
muscle	7%	91.06	53 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.20	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0050673	Biological process	epithelial cell proliferation
GO_0072180	Biological process	mesonephric duct morphogenesis
GO_0001658	Biological process	branching involved in ureteric bud morphogenesis
GO_0007224	Biological process	smoothened signaling pathway
GO_0009948	Biological process	anterior/posterior axis specification
GO_0030324	Biological process	lung development
GO_0046326	Biological process	positive regulation of glucose import
GO_0030316	Biological process	osteoclast differentiation
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0009617	Biological process	response to bacterium
GO_0045879	Biological process	negative regulation of smoothened signaling pathway
GO_0072111	Biological process	cell proliferation involved in kidney development
GO_0045807	Biological process	positive regulation of endocytosis
GO_0060976	Biological process	coronary vasculature development
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0050680	Biological process	negative regulation of epithelial cell proliferation
GO_0035116	Biological process	embryonic hindlimb morphogenesis
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0072138	Biological process	mesenchymal cell proliferation involved in ureteric bud development
GO_0045880	Biological process	positive regulation of smoothened signaling pathway
GO_0045732	Biological process	positive regulation of protein catabolic process
GO_2000050	Biological process	regulation of non-canonical Wnt signaling pathway
GO_0010171	Biological process	body morphogenesis
GO_2000096	Biological process	positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO_0042074	Biological process	cell migration involved in gastrulation
GO_0030282	Biological process	bone mineralization
GO_0030513	Biological process	positive regulation of BMP signaling pathway
GO_0072203	Biological process	cell proliferation involved in metanephros development
GO_1905475	Biological process	regulation of protein localization to membrane
GO_0009653	Biological process	anatomical structure morphogenesis
GO_0060071	Biological process	Wnt signaling pathway, planar cell polarity pathway
GO_0045926	Biological process	negative regulation of growth
GO_0060828	Biological process	regulation of canonical Wnt signaling pathway
GO_0016477	Biological process	cell migration
GO_0005886	Cellular component	plasma membrane
GO_0005796	Cellular component	Golgi lumen
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0009986	Cellular component	cell surface
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0043202	Cellular component	lysosomal lumen
GO_0098552	Cellular component	side of membrane
GO_0060422	Molecular function	peptidyl-dipeptidase inhibitor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	GPC3
Protein name	Glypican-3 Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit]
Synonyms	hCG_14619 OCI5
Description	FUNCTION: Cell surface proteoglycan. . FUNCTION: Cell surface proteoglycan . Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands . Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 . Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity). . FUNCTION: Cell surface proteoglycan. . FUNCTION: Cell surface proteoglycan. . FUNCTION: Cell surface proteoglycan. . FUNCTION: Cell surface proteoglycan. . FUNCTION: Cell surface proteoglycan. . FUNCTION: Cell surface proteoglycan. . FUNCTION: Cell surface proteoglycan. .
Accessions	B4DTD8 ENST00000689310.1 A0A1S5UZ08 ENST00000406757.3 ENST00000394299.7 [P51654-3] Q53H15 Q8IYG2 A0A8I5KYY0 ENST00000631057.2 [P51654-2] ENST00000370818.8 [P51654-1] H0Y3U6 I6QTG3 P51654 ENST00000684880.1 A0A8I5KUG1 ENST00000692084.1

GPC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review