AMER1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of AMER1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AMER1 at tissue level.

III. Associated gene sets

GO_0045732Biological processpositive regulation of protein catabolic process
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0016055Biological processWnt signaling pathway
GO_0060348Biological processbone development
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0060828Biological processregulation of canonical Wnt signaling pathway
GO_0072161Biological processmesenchymal cell differentiation involved in kidney development
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0060612Biological processadipose tissue development
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_1904713Molecular functionbeta-catenin destruction complex binding
GO_0008013Molecular functionbeta-catenin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAMER1
Protein nameAPC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein)
SynonymsWTX
FAM123B
DescriptionFUNCTION: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. .

AccessionsENST00000374869.8 [Q5JTC6-1]
Q5JTC6