DKK4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DKK4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DKK4 at tissue level.

III. Associated gene sets

GO_0030178Biological processnegative regulation of Wnt signaling pathway
GO_0016055Biological processWnt signaling pathway
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0061170Biological processnegative regulation of hair follicle placode formation
GO_0005575Cellular componentcellular_component
GO_0005615Cellular componentextracellular space
GO_0048019Molecular functionreceptor antagonist activity
GO_0039706Molecular functionco-receptor binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameDKK4
Protein nameDickkopf-related protein 4 (Dickkopf-4) (Dkk-4) (hDkk-4) [Cleaved into: Dickkopf-related protein 4 short form]
Synonyms
DescriptionFUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). .

AccessionsQ9UBT3
ENST00000220812.3