CBY1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0055007Biological processcardiac muscle cell differentiation
GO_0051289Biological processprotein homotetramerization
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0030178Biological processnegative regulation of Wnt signaling pathway
GO_0008104Biological processprotein localization
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045444Biological processfat cell differentiation
GO_0033504Biological processfloor plate development
GO_0016607Cellular componentnuclear speck
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005814Cellular componentcentriole
GO_0005802Cellular componenttrans-Golgi network
GO_0005829Cellular componentcytosol
GO_0036064Cellular componentciliary basal body
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0008013Molecular functionbeta-catenin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCBY1
Protein nameProtein chibby homolog 1
Protein chibby homolog 1 (ARPP-binding protein) (Cytosolic leucine-rich protein) (PIGEA-14) (PKD2 interactor, Golgi and endoplasmic reticulum-associated 1)
SynonymsCBY
HRIHFB2025
PGEA1
ARB1
C22orf2
DescriptionFUNCTION: Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. .

AccessionsQ9Y3M2
B0QY53
ENST00000416285.5
ENST00000416285.6
B0QY54
ENST00000411557.6
ENST00000396811.6
ENST00000411557.5
ENST00000216029.8