I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 9 studies | 38% ± 16% | |
| plasmacytoid dendritic cell | 4 studies | 25% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 9 studies | 38% ± 16% | |
| plasmacytoid dendritic cell | 4 studies | 25% ± 10% |
Insufficient scRNA-seq data for expression of FUZ at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 1201.39 | 2642 / 2642 | 100% | 28.74 | 705 / 705 |
| ovary | 100% | 1304.24 | 180 / 180 | 100% | 26.52 | 430 / 430 |
| thymus | 100% | 1179.17 | 653 / 653 | 100% | 23.19 | 605 / 605 |
| prostate | 100% | 1047.22 | 245 / 245 | 99% | 17.45 | 499 / 502 |
| adrenal gland | 100% | 1314.50 | 258 / 258 | 99% | 17.67 | 228 / 230 |
| skin | 99% | 568.45 | 1799 / 1809 | 100% | 20.65 | 470 / 472 |
| kidney | 100% | 1169.31 | 89 / 89 | 99% | 21.04 | 892 / 901 |
| pancreas | 99% | 577.74 | 326 / 328 | 98% | 14.27 | 174 / 178 |
| breast | 100% | 896.02 | 459 / 459 | 96% | 18.83 | 1072 / 1118 |
| uterus | 100% | 1148.71 | 170 / 170 | 93% | 17.10 | 426 / 459 |
| lung | 98% | 721.15 | 569 / 578 | 90% | 11.00 | 1036 / 1155 |
| bladder | 100% | 792.62 | 21 / 21 | 88% | 12.28 | 441 / 504 |
| stomach | 99% | 692.67 | 356 / 359 | 58% | 5.33 | 165 / 286 |
| esophagus | 100% | 722.36 | 1441 / 1445 | 57% | 4.78 | 104 / 183 |
| intestine | 100% | 806.44 | 966 / 966 | 54% | 4.89 | 282 / 527 |
| liver | 93% | 283.79 | 210 / 226 | 51% | 5.41 | 209 / 406 |
| eye | 0% | 0 | 0 / 0 | 100% | 26.74 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 15.16 | 29 / 29 |
| spleen | 100% | 778.16 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.94 | 1 / 1 |
| muscle | 100% | 851.73 | 801 / 803 | 0% | 0 | 0 / 0 |
| adipose | 100% | 687.50 | 1199 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 568.20 | 1324 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 606.06 | 843 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 95% | 496.94 | 885 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 11.24 | 39 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0008589 | Biological process | regulation of smoothened signaling pathway |
| GO_1905515 | Biological process | non-motile cilium assembly |
| GO_0060271 | Biological process | cilium assembly |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0090301 | Biological process | negative regulation of neural crest formation |
| GO_0010172 | Biological process | embryonic body morphogenesis |
| GO_0048704 | Biological process | embryonic skeletal system morphogenesis |
| GO_1902017 | Biological process | regulation of cilium assembly |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_0016192 | Biological process | vesicle-mediated transport |
| GO_0045724 | Biological process | positive regulation of cilium assembly |
| GO_2000314 | Biological process | negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation |
| GO_0001843 | Biological process | neural tube closure |
| GO_0001942 | Biological process | hair follicle development |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0015031 | Biological process | protein transport |
| GO_0042073 | Biological process | intraciliary transport |
| GO_0021915 | Biological process | neural tube development |
| GO_0001736 | Biological process | establishment of planar polarity |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005929 | Cellular component | cilium |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005515 | Molecular function | protein binding |
| Gene name | FUZ |
| Protein name | Fuzzy planar cell polarity protein Protein fuzzy homolog |
| Synonyms | FY |
| Description | FUNCTION: Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity). . |
| Accessions | M0QYX9 M0R0M0 ENST00000377092.8 ENST00000527111.2 ENST00000529634.2 E9PKJ4 E9PLA3 ENST00000525130.5 E9PS25 ENST00000527585.5 Q9BT04 ENST00000528043.5 ENST00000525370.5 E9PK12 M0R1D4 ENST00000526575.1 ENST00000526435.1 ENST00000529302.1 ENST00000533418.5 M0QZY8 ENST00000525800.5 M0QYI7 ENST00000528094.5 [Q9BT04-3] ENST00000313777.9 [Q9BT04-1] G5E9A4 |
