DAB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032349Biological processpositive regulation of aldosterone biosynthetic process
GO_0006898Biological processreceptor-mediated endocytosis
GO_0035026Biological processleading edge cell differentiation
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_2000860Biological processpositive regulation of aldosterone secretion
GO_2000643Biological processpositive regulation of early endosome to late endosome transport
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0045807Biological processpositive regulation of endocytosis
GO_0060391Biological processpositive regulation of SMAD protein signal transduction
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_1902074Biological processresponse to salt
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0048268Biological processclathrin coat assembly
GO_0010977Biological processnegative regulation of neuron projection development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_2000096Biological processpositive regulation of Wnt signaling pathway, planar cell polarity pathway
GO_0060766Biological processnegative regulation of androgen receptor signaling pathway
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0006915Biological processapoptotic process
GO_0048545Biological processresponse to steroid hormone
GO_0015031Biological processprotein transport
GO_1903077Biological processnegative regulation of protein localization to plasma membrane
GO_1900026Biological processpositive regulation of substrate adhesion-dependent cell spreading
GO_0016055Biological processWnt signaling pathway
GO_2000370Biological processpositive regulation of clathrin-dependent endocytosis
GO_0032091Biological processnegative regulation of protein binding
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0030308Biological processnegative regulation of cell growth
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0030136Cellular componentclathrin-coated vesicle
GO_0001650Cellular componentfibrillar center
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005905Cellular componentclathrin-coated pit
GO_0030665Cellular componentclathrin-coated vesicle membrane
GO_0005765Cellular componentlysosomal membrane
GO_0038024Molecular functioncargo receptor activity
GO_0046332Molecular functionSMAD binding
GO_0050750Molecular functionlow-density lipoprotein particle receptor binding
GO_0035615Molecular functionclathrin adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDAB2
Protein nameDisabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)
DAB adaptor protein 2
SynonymsDOC2
DescriptionFUNCTION: Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. .

AccessionsD6RGZ1
ENST00000320816.11 [P98082-1]
ENST00000339788.10 [P98082-2]
ENST00000509337.5 [P98082-3]
D6REB1
D6RIA5
D6RFF7
ENST00000515700.5
ENST00000507539.5
ENST00000545653.5 [P98082-3]
ENST00000503513.5
ENST00000511792.5
P98082