CSNK1A1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	50 studies	48% ± 14%	Explore
fibroblast	43 studies	40% ± 13%	Explore
macrophage	37 studies	36% ± 13%	Explore
B cell	36 studies	26% ± 8%	Explore
natural killer cell	35 studies	28% ± 7%	Explore
pericyte	35 studies	38% ± 12%	Explore
smooth muscle cell	33 studies	38% ± 10%	Explore
T cell	30 studies	28% ± 8%	Explore
CD4-positive, alpha-beta T cell	30 studies	27% ± 9%	Explore
CD8-positive, alpha-beta T cell	29 studies	26% ± 8%	Explore
conventional dendritic cell	28 studies	35% ± 12%	Explore
classical monocyte	25 studies	38% ± 13%	Explore
mast cell	24 studies	33% ± 14%	Explore
basal cell	23 studies	53% ± 18%	Explore
epithelial cell	23 studies	45% ± 20%	Explore
regulatory T cell	23 studies	30% ± 6%	Explore
endothelial cell of lymphatic vessel	22 studies	38% ± 11%	Explore
non-classical monocyte	21 studies	34% ± 13%	Explore
monocyte	20 studies	38% ± 10%	Explore
astrocyte	20 studies	45% ± 17%	Explore
memory B cell	19 studies	25% ± 4%	Explore
ciliated cell	19 studies	54% ± 15%	Explore
naive B cell	19 studies	23% ± 6%	Explore
dendritic cell	18 studies	43% ± 20%	Explore
plasmacytoid dendritic cell	17 studies	33% ± 11%	Explore
connective tissue cell	17 studies	37% ± 11%	Explore
oligodendrocyte precursor cell	17 studies	44% ± 17%	Explore
mature NK T cell	17 studies	27% ± 7%	Explore
gamma-delta T cell	17 studies	31% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	27% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	29% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	29% ± 8%	Explore
capillary endothelial cell	15 studies	39% ± 9%	Explore
myofibroblast cell	15 studies	37% ± 12%	Explore
oligodendrocyte	15 studies	41% ± 13%	Explore
microglial cell	15 studies	42% ± 14%	Explore
endothelial cell of vascular tree	14 studies	43% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	28% ± 8%	Explore
glutamatergic neuron	13 studies	46% ± 21%	Explore
endothelial cell of artery	13 studies	46% ± 12%	Explore
vein endothelial cell	13 studies	44% ± 11%	Explore
mucosal invariant T cell	13 studies	27% ± 4%	Explore
myeloid cell	13 studies	41% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	30% ± 7%	Explore
type II pneumocyte	11 studies	39% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	28% ± 6%	Explore
club cell	11 studies	48% ± 14%	Explore
secretory cell	11 studies	52% ± 12%	Explore
GABAergic neuron	11 studies	48% ± 19%	Explore
type I pneumocyte	10 studies	38% ± 9%	Explore
leukocyte	10 studies	33% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	32% ± 8%	Explore
abnormal cell	10 studies	40% ± 19%	Explore
neuron	10 studies	46% ± 19%	Explore
plasma cell	9 studies	28% ± 11%	Explore
goblet cell	9 studies	41% ± 20%	Explore
mesothelial cell	9 studies	39% ± 12%	Explore
adipocyte	9 studies	48% ± 13%	Explore
alveolar macrophage	8 studies	34% ± 14%	Explore
respiratory goblet cell	8 studies	50% ± 14%	Explore
progenitor cell	8 studies	29% ± 6%	Explore
neutrophil	7 studies	23% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	26% ± 4%	Explore
mononuclear phagocyte	7 studies	42% ± 10%	Explore
kidney loop of Henle epithelial cell	7 studies	23% ± 5%	Explore
amacrine cell	7 studies	36% ± 11%	Explore
interneuron	7 studies	49% ± 23%	Explore
retinal cone cell	7 studies	34% ± 9%	Explore
T follicular helper cell	7 studies	29% ± 3%	Explore
hematopoietic precursor cell	6 studies	42% ± 19%	Explore
ionocyte	6 studies	39% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	26% ± 4%	Explore
hematopoietic stem cell	6 studies	32% ± 12%	Explore
lymphocyte	6 studies	39% ± 12%	Explore
precursor B cell	6 studies	31% ± 11%	Explore
innate lymphoid cell	6 studies	34% ± 8%	Explore
retina horizontal cell	6 studies	42% ± 13%	Explore
retinal rod cell	6 studies	30% ± 8%	Explore
mucus secreting cell	6 studies	33% ± 15%	Explore
Mueller cell	6 studies	48% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	31% ± 11%	Explore
plasmablast	5 studies	47% ± 18%	Explore
platelet	5 studies	21% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	30% ± 7%	Explore
enteroendocrine cell	5 studies	38% ± 16%	Explore
retinal bipolar neuron	5 studies	31% ± 5%	Explore
glial cell	5 studies	35% ± 18%	Explore
retinal ganglion cell	5 studies	49% ± 22%	Explore
pro-B cell	5 studies	31% ± 3%	Explore
brush cell	5 studies	40% ± 20%	Explore
adventitial cell	5 studies	31% ± 9%	Explore
cardiac muscle cell	5 studies	60% ± 6%	Explore
myoepithelial cell	5 studies	56% ± 14%	Explore
erythrocyte	5 studies	34% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	25% ± 4%	Explore
deuterosomal cell	4 studies	30% ± 10%	Explore
duct epithelial cell	4 studies	42% ± 18%	Explore
squamous epithelial cell	4 studies	56% ± 15%	Explore
pancreatic A cell	4 studies	52% ± 10%	Explore
type B pancreatic cell	4 studies	48% ± 20%	Explore
endothelial cell of sinusoid	4 studies	35% ± 15%	Explore
exhausted T cell	4 studies	34% ± 11%	Explore
epithelial cell of proximal tubule	4 studies	23% ± 5%	Explore
renal alpha-intercalated cell	4 studies	30% ± 9%	Explore
enterocyte	4 studies	20% ± 5%	Explore
granule cell	4 studies	40% ± 12%	Explore
erythroblast	4 studies	34% ± 19%	Explore
immature B cell	4 studies	24% ± 4%	Explore
retinal pigment epithelial cell	4 studies	45% ± 15%	Explore
OFF-bipolar cell	4 studies	31% ± 9%	Explore
ON-bipolar cell	4 studies	37% ± 9%	Explore
intermediate monocyte	4 studies	43% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	79% ± 4%	Explore
hepatocyte	4 studies	55% ± 21%	Explore
granulocyte	4 studies	33% ± 14%	Explore
luminal cell of prostate epithelium	4 studies	68% ± 4%	Explore
muscle cell	4 studies	45% ± 13%	Explore
keratinocyte	4 studies	61% ± 17%	Explore
T-helper 17 cell	4 studies	28% ± 5%	Explore
renal principal cell	4 studies	29% ± 6%	Explore
hillock cell	3 studies	51% ± 9%	Explore
precursor cell	3 studies	36% ± 11%	Explore
pancreatic D cell	3 studies	47% ± 18%	Explore
glomerular endothelial cell	3 studies	38% ± 3%	Explore
podocyte	3 studies	46% ± 8%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	45% ± 11%	Explore
intestinal crypt stem cell	3 studies	23% ± 7%	Explore
neural crest cell	3 studies	38% ± 5%	Explore
transit amplifying cell	3 studies	44% ± 27%	Explore
GABAergic interneuron	3 studies	37% ± 7%	Explore
extravillous trophoblast	3 studies	56% ± 13%	Explore
placental villous trophoblast	3 studies	62% ± 19%	Explore
megakaryocyte	3 studies	34% ± 19%	Explore
tissue-resident macrophage	3 studies	42% ± 7%	Explore
GABAergic amacrine cell	3 studies	43% ± 8%	Explore
glycinergic amacrine cell	3 studies	38% ± 3%	Explore
rod bipolar cell	3 studies	48% ± 12%	Explore
germinal center B cell	3 studies	27% ± 3%	Explore
CD4-positive helper T cell	3 studies	32% ± 8%	Explore
pancreatic ductal cell	3 studies	57% ± 15%	Explore
neural progenitor cell	3 studies	44% ± 8%	Explore
ependymal cell	3 studies	51% ± 9%	Explore
chondrocyte	3 studies	38% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 14%	Explore
Schwann cell	3 studies	35% ± 5%	Explore
melanocyte	3 studies	34% ± 10%	Explore
T-helper 1 cell	3 studies	29% ± 5%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	27% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	24% ± 5%	Explore
double negative thymocyte	3 studies	46% ± 18%	Explore
progenitor cell of mammary luminal epithelium	3 studies	41% ± 7%	Explore
mural cell	3 studies	55% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	21 studies	42% ± 18%	Explore
lung	19 studies	41% ± 16%	Explore
peripheral blood	16 studies	32% ± 11%	Explore
intestine	11 studies	27% ± 13%	Explore
eye	11 studies	34% ± 13%	Explore
kidney	9 studies	30% ± 7%	Explore
liver	6 studies	39% ± 19%	Explore
heart	5 studies	45% ± 6%	Explore
lymph node	5 studies	27% ± 5%	Explore
breast	5 studies	43% ± 10%	Explore
pancreas	4 studies	49% ± 15%	Explore
bone marrow	4 studies	32% ± 15%	Explore
uterus	4 studies	49% ± 13%	Explore
prostate	4 studies	55% ± 8%	Explore
adipose	4 studies	40% ± 17%	Explore
placenta	3 studies	57% ± 17%	Explore
esophagus	3 studies	51% ± 16%	Explore
skin	3 studies	43% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	18310.87	1445 / 1445	100%	44.66	183 / 183
prostate	100%	16012.41	245 / 245	100%	43.27	501 / 502
intestine	100%	13785.90	966 / 966	99%	31.60	524 / 527
stomach	100%	9814.67	359 / 359	99%	30.73	284 / 286
lung	100%	13790.89	577 / 578	99%	34.38	1148 / 1155
breast	100%	13517.95	459 / 459	99%	50.62	1103 / 1118
brain	99%	8148.15	2628 / 2642	99%	32.50	699 / 705
uterus	100%	12762.58	170 / 170	98%	32.50	449 / 459
ovary	100%	9682.34	180 / 180	98%	24.56	420 / 430
pancreas	99%	5024.64	324 / 328	98%	27.83	175 / 178
thymus	100%	11613.73	653 / 653	97%	25.49	587 / 605
bladder	100%	13286.00	21 / 21	97%	28.03	487 / 504
kidney	100%	8311.24	89 / 89	92%	24.96	833 / 901
skin	100%	19332.90	1809 / 1809	92%	27.53	436 / 472
adrenal gland	100%	12509.78	258 / 258	88%	21.02	202 / 230
liver	100%	6241.01	226 / 226	72%	10.22	294 / 406
adipose	100%	12823.38	1204 / 1204	0%	0	0 / 0
blood vessel	100%	13295.85	1335 / 1335	0%	0	0 / 0
muscle	100%	9902.44	803 / 803	0%	0	0 / 0
spleen	100%	9061.63	241 / 241	0%	0	0 / 0
heart	98%	10534.49	845 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	47.99	44 / 45
peripheral blood	92%	6570.23	851 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	83%	16.24	24 / 29
eye	0%	0	0 / 0	78%	13.87	62 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_1900226	Biological process	negative regulation of NLRP3 inflammasome complex assembly
GO_0007165	Biological process	signal transduction
GO_0032436	Biological process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0031670	Biological process	cellular response to nutrient
GO_0051301	Biological process	cell division
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0007030	Biological process	Golgi organization
GO_0045104	Biological process	intermediate filament cytoskeleton organization
GO_0019082	Biological process	viral protein processing
GO_0016055	Biological process	Wnt signaling pathway
GO_0006468	Biological process	protein phosphorylation
GO_0035025	Biological process	positive regulation of Rho protein signal transduction
GO_1904263	Biological process	positive regulation of TORC1 signaling
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0016020	Cellular component	membrane
GO_0016607	Cellular component	nuclear speck
GO_0005813	Cellular component	centrosome
GO_0000776	Cellular component	kinetochore
GO_0005847	Cellular component	mRNA cleavage and polyadenylation specificity factor complex
GO_0030877	Cellular component	beta-catenin destruction complex
GO_0005929	Cellular component	cilium
GO_0005829	Cellular component	cytosol
GO_0045095	Cellular component	keratin filament
GO_0005737	Cellular component	cytoplasm
GO_0036064	Cellular component	ciliary basal body
GO_0005819	Cellular component	spindle
GO_0005634	Cellular component	nucleus
GO_0106310	Molecular function	protein serine kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0004672	Molecular function	protein kinase activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CSNK1A1
Protein name	non-specific serine/threonine protein kinase (EC 2.7.11.1) Casein kinase 1 alpha 1 Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1)
Synonyms	hCG_201512
Description	FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates . It can phosphorylate a large number of proteins . Participates in Wnt signaling . Phosphorylates CTNNB1 at 'Ser-45' . May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis . May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration . Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor . Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). .
Accessions	ENST00000606826.5 A0A590UK94 D6REM4 P48729 A0A5F9W493 ENST00000606719.6 E7ETM0 U3KPX3 Q05DL3 ENST00000661952.1 Q6PJ06 U3KQ83 ENST00000657462.1 ENST00000515768.6 ENST00000670598.1 ENST00000523203.5 A0A590UJQ7 ENST00000606299.2 A0A590UJ43 ENST00000657001.1 [P48729-3] D6RGE5 E5RG27 H0Y9X2 ENST00000657706.1 U3KQK7 ENST00000515435.5 ENST00000261798.10 [P48729-2] ENST00000515748.2 ENST00000504676.5 ENST00000503350.6 ENST00000377843.8 [P48729-1]

CSNK1A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review