AMFR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000209Biological processprotein polyubiquitination
GO_0007611Biological processlearning or memory
GO_2000638Biological processregulation of SREBP signaling pathway
GO_0007165Biological processsignal transduction
GO_0051865Biological processprotein autoubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0044314Biological processprotein K27-linked ubiquitination
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0016055Biological processWnt signaling pathway
GO_0036503Biological processERAD pathway
GO_0000151Cellular componentubiquitin ligase complex
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005794Cellular componentGolgi apparatus
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0030426Cellular componentgrowth cone
GO_0036513Cellular componentDerlin-1 retrotranslocation complex
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0038023Molecular functionsignaling receptor activity
GO_1904288Molecular functionBAT3 complex binding
GO_0034450Molecular functionubiquitin-ubiquitin ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0046872Molecular functionmetal ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding
GO_1990381Molecular functionubiquitin-specific protease binding

IV. Literature review

[source]
Gene nameAMFR
Protein nameE3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78)
Autocrine motility factor receptor
AMFR protein
SynonymsRNF45
DescriptionFUNCTION: E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation . Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) . The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane . In addition, interaction of AMFR with AUP1 facilitates interaction of AMFR with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase RNF139, leading to sterol-induced HMGCR ubiquitination . The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction . In addition to ubiquitination on lysine residues, catalyzes ubiquitination on cysteine residues: together with INSIG1, mediates polyubiquitination of SOAT2/ACAT2 at 'Cys-277', leading to its degradation when the lipid levels are low . Catalyzes ubiquitination and subsequent degradation of INSIG1 when cells are depleted of sterols . Mediates polyubiquitination of INSIG2 at 'Cys-215' in some tissues, leading to its degradation . Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex . Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation . Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor . In association with LMBR1L and UBAC2, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 . Regulates NF-kappa-B and MAPK signaling pathways by mediating 'Lys-27'-linked polyubiquitination of TAB3 and promoting subsequent TAK1/MAP3K7 activation . Required for proper lipid homeostasis . .

AccessionsENST00000565445.5
ENST00000492830.5
ENST00000567738.1
H3BSK3
ENST00000563664.1
ENST00000290649.10
H3BRK9
Q1RN03
Q9UKV5
R4GNG2
H3BQM3
Q6PGR1