HDAC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_1902455Biological processnegative regulation of stem cell population maintenance
GO_0060789Biological processhair follicle placode formation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0021766Biological processhippocampus development
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0010629Biological processnegative regulation of gene expression
GO_2000736Biological processregulation of stem cell differentiation
GO_2000273Biological processpositive regulation of signaling receptor activity
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0043922Biological processnegative regulation by host of viral transcription
GO_0010628Biological processpositive regulation of gene expression
GO_0006346Biological processDNA methylation-dependent heterochromatin formation
GO_0042733Biological processembryonic digit morphogenesis
GO_0006476Biological processprotein deacetylation
GO_0061198Biological processfungiform papilla formation
GO_0009913Biological processepidermal cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0032922Biological processcircadian regulation of gene expression
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0031507Biological processheterochromatin formation
GO_0030182Biological processneuron differentiation
GO_0042659Biological processregulation of cell fate specification
GO_0010832Biological processnegative regulation of myotube differentiation
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0007492Biological processendoderm development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0048714Biological processpositive regulation of oligodendrocyte differentiation
GO_0060766Biological processnegative regulation of androgen receptor signaling pathway
GO_0048709Biological processoligodendrocyte differentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0030336Biological processnegative regulation of cell migration
GO_2001243Biological processnegative regulation of intrinsic apoptotic signaling pathway
GO_0061029Biological processeyelid development in camera-type eye
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0036120Biological processcellular response to platelet-derived growth factor stimulus
GO_0000792Cellular componentheterochromatin
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0070822Cellular componentSin3-type complex
GO_0043025Cellular componentneuronal cell body
GO_0017053Cellular componenttranscription repressor complex
GO_0000118Cellular componenthistone deacetylase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0016581Cellular componentNuRD complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0033558Molecular functionprotein lysine deacetylase activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001046Molecular functioncore promoter sequence-specific DNA binding
GO_0004407Molecular functionhistone deacetylase activity
GO_0031492Molecular functionnucleosomal DNA binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0001222Molecular functiontranscription corepressor binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0035851Molecular functionKrueppel-associated box domain binding
GO_0002039Molecular functionp53 binding
GO_0070888Molecular functionE-box binding
GO_0160009Molecular functionhistone decrotonylase activity
GO_0005515Molecular functionprotein binding
GO_0000979Molecular functionRNA polymerase II core promoter sequence-specific DNA binding
GO_0051059Molecular functionNF-kappaB binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameHDAC1
Protein nameHistone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Histone deacetylase 1
Histone deacetylase (EC 3.5.1.98)
Histone deacetylase 1 (EC 3.5.1.98) (Protein deacetylase HDAC1) (Protein decrotonylase HDAC1)
SynonymsRPD3L1
hCG_41610
DescriptionFUNCTION: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events . Histone deacetylases act via the formation of large multiprotein complexes . Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin . As part of the SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription . Also functions as a deacetylase for non-histone targets, such as NR1D2, RELA, SP1, SP3, STAT3 and TSHZ3 . Deacetylates SP proteins, SP1 and SP3, and regulates their function . Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons . Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation . Deacetylates TSHZ3 and regulates its transcriptional repressor activity . Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B . Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity . Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer (By similarity). Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation (By similarity). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones . .

AccessionsB5MGH2
Q6IT96
B5BU61
Q5TEE2
Q13547
ENST00000373548.8
ENST00000428704.1