Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 16 studies | 59% ± 22% | |
endothelial cell | 8 studies | 27% ± 10% | |
oligodendrocyte precursor cell | 8 studies | 26% ± 8% | |
glutamatergic neuron | 7 studies | 36% ± 22% | |
type II pneumocyte | 5 studies | 37% ± 14% | |
granule cell | 4 studies | 31% ± 9% | |
adipocyte | 4 studies | 21% ± 3% | |
epithelial cell | 4 studies | 29% ± 9% | |
GABAergic neuron | 4 studies | 36% ± 15% | |
hepatocyte | 3 studies | 46% ± 21% | |
oligodendrocyte | 3 studies | 23% ± 6% | |
smooth muscle cell | 3 studies | 33% ± 15% | |
ependymal cell | 3 studies | 45% ± 18% | |
club cell | 3 studies | 27% ± 12% | |
fibroblast | 3 studies | 18% ± 2% | |
transit amplifying cell | 3 studies | 29% ± 11% | |
interneuron | 3 studies | 28% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 1429.33 | 244 / 245 | 99% | 17.29 | 498 / 502 |
brain | 99% | 1967.50 | 2620 / 2642 | 100% | 19.74 | 702 / 705 |
ovary | 100% | 1682.57 | 180 / 180 | 98% | 12.83 | 422 / 430 |
intestine | 99% | 1076.33 | 957 / 966 | 97% | 22.12 | 512 / 527 |
esophagus | 100% | 1143.69 | 1445 / 1445 | 96% | 15.37 | 176 / 183 |
kidney | 100% | 1871.09 | 89 / 89 | 96% | 15.37 | 866 / 901 |
lung | 99% | 944.96 | 571 / 578 | 97% | 12.80 | 1119 / 1155 |
stomach | 100% | 1185.45 | 358 / 359 | 96% | 22.21 | 274 / 286 |
thymus | 100% | 1066.29 | 651 / 653 | 95% | 13.62 | 574 / 605 |
breast | 100% | 931.38 | 458 / 459 | 95% | 11.84 | 1057 / 1118 |
bladder | 100% | 1122.57 | 21 / 21 | 92% | 12.85 | 464 / 504 |
uterus | 100% | 1460.03 | 170 / 170 | 91% | 9.48 | 418 / 459 |
pancreas | 97% | 638.24 | 318 / 328 | 93% | 7.59 | 166 / 178 |
skin | 100% | 1422.97 | 1808 / 1809 | 89% | 7.66 | 419 / 472 |
liver | 100% | 903.42 | 226 / 226 | 83% | 12.38 | 335 / 406 |
adrenal gland | 100% | 2046.10 | 258 / 258 | 79% | 7.89 | 181 / 230 |
blood vessel | 100% | 1871.44 | 1335 / 1335 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.41 | 1 / 1 |
adipose | 100% | 857.05 | 1200 / 1204 | 0% | 0 | 0 / 0 |
muscle | 98% | 740.14 | 783 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 8.34 | 41 / 45 |
heart | 89% | 556.29 | 764 / 861 | 0% | 0 | 0 / 0 |
spleen | 48% | 175.38 | 115 / 241 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 38% | 1.60 | 30 / 80 |
lymph node | 0% | 0 | 0 / 0 | 3% | 0.11 | 1 / 29 |
peripheral blood | 0% | 0.94 | 3 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0060173 | Biological process | limb development |
GO_0016567 | Biological process | protein ubiquitination |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0016055 | Biological process | Wnt signaling pathway |
GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
GO_2000051 | Biological process | negative regulation of non-canonical Wnt signaling pathway |
GO_2000095 | Biological process | regulation of Wnt signaling pathway, planar cell polarity pathway |
GO_0038018 | Biological process | Wnt receptor catabolic process |
GO_0072089 | Biological process | stem cell proliferation |
GO_0005886 | Cellular component | plasma membrane |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0005109 | Molecular function | frizzled binding |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | ZNRF3 |
Protein name | ZNRF3 protein E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3) |
Synonyms | RNF203 KIAA1133 |
Description | FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone . Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity). . |
Accessions | ENST00000402174.5 [Q9ULT6-2] Q9ULT6 ENST00000406323.3 [Q9ULT6-2] ENST00000544604.7 [Q9ULT6-1] Q96GS9 |