AMER2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016055Biological processWnt signaling pathway
GO_0060828Biological processregulation of canonical Wnt signaling pathway
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0007398Biological processectoderm development
GO_0005886Cellular componentplasma membrane
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0008013Molecular functionbeta-catenin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAMER2
Protein nameAPC membrane recruitment protein 2 (Amer2) (Protein FAM123A)
SynonymsFAM123A
DescriptionFUNCTION: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. .

AccessionsENST00000515384.2 [Q8N7J2-1]
Q8N7J2
ENST00000357816.2 [Q8N7J2-2]