SCYL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007420Biological processbrain development
GO_0072583Biological processclathrin-dependent endocytosis
GO_0031623Biological processreceptor internalization
GO_0008333Biological processendosome to lysosome transport
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0021860Biological processpyramidal neuron development
GO_0010008Cellular componentendosome membrane
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding
GO_0004672Molecular functionprotein kinase activity

IV. Literature review

[source]
Gene nameSCYL2
Protein nameSCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa)
SCY1 like pseudokinase 2
SynonymsCVAK104
KIAA1360
DescriptionFUNCTION: Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed . By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (By similarity). .

AccessionsH0YIK6
F8VSC5
ENST00000550251.2
F8VPW3
Q6P3W7
ENST00000635101.1
A0A0U1RQQ9
H0YI32
ENST00000548871.1
ENST00000360820.7
ENST00000548392.5
ENST00000549687.5