LATS2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LATS2 at tissue level.

III. Associated gene sets

GO_0046620Biological processregulation of organ growth
GO_0017015Biological processregulation of transforming growth factor beta receptor signaling pathway
GO_0030216Biological processkeratinocyte differentiation
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0035329Biological processhippo signaling
GO_0001827Biological processinner cell mass cell fate commitment
GO_0051301Biological processcell division
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0009755Biological processhormone-mediated signaling pathway
GO_1900181Biological processnegative regulation of protein localization to nucleus
GO_0008104Biological processprotein localization
GO_0006468Biological processprotein phosphorylation
GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0001828Biological processinner cell mass cellular morphogenesis
GO_0043065Biological processpositive regulation of apoptotic process
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0034451Cellular componentcentriolar satellite
GO_0000922Cellular componentspindle pole
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLATS2
Protein nameSerine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
SynonymsKPM
DescriptionFUNCTION: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ. .

AccessionsENST00000382592.5
Q9NRM7