EMD | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	20 studies	32% ± 9%	Explore
natural killer cell	19 studies	28% ± 8%	Explore
CD4-positive, alpha-beta T cell	19 studies	30% ± 11%	Explore
regulatory T cell	19 studies	30% ± 7%	Explore
memory B cell	17 studies	25% ± 7%	Explore
B cell	16 studies	26% ± 7%	Explore
classical monocyte	16 studies	21% ± 6%	Explore
naive B cell	16 studies	22% ± 5%	Explore
smooth muscle cell	14 studies	26% ± 11%	Explore
T cell	13 studies	25% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	31% ± 7%	Explore
macrophage	13 studies	20% ± 3%	Explore
plasmacytoid dendritic cell	12 studies	27% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	27% ± 6%	Explore
non-classical monocyte	12 studies	22% ± 7%	Explore
pericyte	12 studies	25% ± 11%	Explore
gamma-delta T cell	12 studies	34% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	34% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	30% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	24% ± 6%	Explore
mature NK T cell	10 studies	28% ± 8%	Explore
mucosal invariant T cell	10 studies	34% ± 7%	Explore
fibroblast	10 studies	25% ± 8%	Explore
conventional dendritic cell	9 studies	29% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	33% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	31% ± 9%	Explore
mast cell	7 studies	26% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	30% ± 10%	Explore
epithelial cell	7 studies	37% ± 17%	Explore
monocyte	6 studies	20% ± 4%	Explore
plasma cell	6 studies	36% ± 9%	Explore
plasmablast	6 studies	39% ± 21%	Explore
basal cell	6 studies	22% ± 7%	Explore
dendritic cell	6 studies	30% ± 15%	Explore
myofibroblast cell	6 studies	28% ± 7%	Explore
ciliated cell	6 studies	28% ± 9%	Explore
connective tissue cell	6 studies	27% ± 13%	Explore
endothelial cell	6 studies	24% ± 8%	Explore
T follicular helper cell	6 studies	29% ± 6%	Explore
abnormal cell	6 studies	28% ± 8%	Explore
platelet	6 studies	27% ± 12%	Explore
hematopoietic stem cell	5 studies	22% ± 6%	Explore
innate lymphoid cell	5 studies	25% ± 5%	Explore
myeloid cell	5 studies	23% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	34% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	32% ± 7%	Explore
exhausted T cell	4 studies	35% ± 5%	Explore
megakaryocyte	4 studies	32% ± 10%	Explore
precursor B cell	4 studies	27% ± 5%	Explore
pro-B cell	4 studies	24% ± 4%	Explore
erythrocyte	4 studies	26% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	26% ± 7%	Explore
club cell	3 studies	21% ± 3%	Explore
secretory cell	3 studies	19% ± 3%	Explore
leukocyte	3 studies	19% ± 3%	Explore
erythroblast	3 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	3 studies	21% ± 2%	Explore
immature B cell	3 studies	25% ± 7%	Explore
type I pneumocyte	3 studies	27% ± 7%	Explore
granulocyte	3 studies	17% ± 1%	Explore
muscle cell	3 studies	26% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 4%	Explore
goblet cell	3 studies	20% ± 2%	Explore
T-helper 1 cell	3 studies	35% ± 12%	Explore
double negative thymocyte	3 studies	36% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	26% ± 5%	Explore
lung	7 studies	21% ± 4%	Explore
lymph node	4 studies	26% ± 5%	Explore
bone marrow	3 studies	22% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4476.54	1445 / 1445	100%	87.99	183 / 183
liver	100%	1756.39	226 / 226	100%	79.81	406 / 406
ovary	100%	7174.74	180 / 180	100%	137.86	430 / 430
skin	100%	4213.36	1809 / 1809	100%	120.66	472 / 472
thymus	100%	4869.44	653 / 653	100%	141.76	605 / 605
uterus	100%	5881.70	170 / 170	100%	149.08	459 / 459
prostate	100%	4458.74	245 / 245	100%	126.26	501 / 502
pancreas	100%	2623.35	327 / 328	100%	91.86	178 / 178
stomach	100%	3302.77	359 / 359	100%	110.79	285 / 286
intestine	100%	4016.95	966 / 966	100%	119.17	525 / 527
adrenal gland	100%	3290.52	258 / 258	100%	122.01	229 / 230
kidney	100%	3717.69	89 / 89	99%	90.49	896 / 901
bladder	100%	5539.29	21 / 21	99%	119.05	500 / 504
brain	99%	2518.48	2620 / 2642	100%	95.65	705 / 705
breast	100%	4023.85	459 / 459	99%	124.43	1107 / 1118
lung	100%	4040.04	578 / 578	99%	106.90	1140 / 1155
blood vessel	100%	5805.50	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	124.92	80 / 80
lymph node	0%	0	0 / 0	100%	111.29	29 / 29
spleen	100%	3157.67	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	125.61	45 / 45
ureter	0%	0	0 / 0	100%	73.02	1 / 1
adipose	100%	3782.87	1203 / 1204	0%	0	0 / 0
muscle	100%	4199.30	802 / 803	0%	0	0 / 0
heart	98%	3051.39	846 / 861	0%	0	0 / 0
peripheral blood	94%	3853.78	869 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0048147	Biological process	negative regulation of fibroblast proliferation
GO_0046827	Biological process	positive regulation of protein export from nucleus
GO_0006936	Biological process	muscle contraction
GO_0071363	Biological process	cellular response to growth factor stimulus
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0071763	Biological process	nuclear membrane organization
GO_0007517	Biological process	muscle organ development
GO_0035914	Biological process	skeletal muscle cell differentiation
GO_0060828	Biological process	regulation of canonical Wnt signaling pathway
GO_0032541	Cellular component	cortical endoplasmic reticulum
GO_0005874	Cellular component	microtubule
GO_0160045	Cellular component	TMEM240-body
GO_0016020	Cellular component	membrane
GO_0031616	Cellular component	spindle pole centrosome
GO_0005654	Cellular component	nucleoplasm
GO_0005637	Cellular component	nuclear inner membrane
GO_0005635	Cellular component	nuclear envelope
GO_0005640	Cellular component	nuclear outer membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0031965	Cellular component	nuclear membrane
GO_0005819	Cellular component	spindle
GO_0048487	Molecular function	beta-tubulin binding
GO_0045296	Molecular function	cadherin binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

IV. Literature review

[source]

Gene name	EMD
Protein name	Emerin
Synonyms	hCG_41343 EDMD STA
Description	FUNCTION: Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells . EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. .
Accessions	A0A804HIV7 ENST00000428228.5 ENST00000683627.1 P50402 ENST00000369842.9 F8WEQ1 ENST00000682114.1 Q5HY57 ENST00000369835.3 A0A804HIG7 ENST00000684678.1 A0A804HLA2 ENST00000684082.1

EMD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review