FZD1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FZD1 at tissue level.

III. Associated gene sets

GO_0003151Biological processoutflow tract morphogenesis
GO_1905606Biological processregulation of presynapse assembly
GO_0035425Biological processautocrine signaling
GO_1903377Biological processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_1904948Biological processmidbrain dopaminergic neuron differentiation
GO_0045446Biological processendothelial cell differentiation
GO_0010976Biological processpositive regulation of neuron projection development
GO_0003149Biological processmembranous septum morphogenesis
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_2000739Biological processregulation of mesenchymal stem cell differentiation
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0007267Biological processcell-cell signaling
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0044338Biological processcanonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
GO_0090179Biological processplanar cell polarity pathway involved in neural tube closure
GO_0030182Biological processneuron differentiation
GO_0003150Biological processmuscular septum morphogenesis
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0099054Biological processpresynapse assembly
GO_0060022Biological processhard palate development
GO_0036520Biological processastrocyte-dopaminergic neuron signaling
GO_0035567Biological processnon-canonical Wnt signaling pathway
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005886Cellular componentplasma membrane
GO_0005925Cellular componentfocal adhesion
GO_0009986Cellular componentcell surface
GO_1990909Cellular componentWnt signalosome
GO_0017147Molecular functionWnt-protein binding
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0005109Molecular functionfrizzled binding
GO_0005102Molecular functionsignaling receptor binding
GO_0042813Molecular functionWnt receptor activity
GO_0030165Molecular functionPDZ domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFZD1
Protein nameFrizzled-1 (Fz-1) (hFz1) (FzE1)
Synonyms
DescriptionFUNCTION: Receptor for Wnt proteins . Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B . Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway . The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes . A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). .; FUNCTION: (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. .

AccessionsENST00000287934.4
Q9UP38